Evidence map›Paper›PMID 28238948›Full record

ReviewSeminars in cell & developmental biology2017

Mechanisms of embryonic stomach development.

Kyle W McCracken, James M Wells

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Gastric hypoplasia in mice lacking fibroblast growth factor 9.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Morphogen Signals Shaping the Gastric Glands in Health and Disease.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Review
  18. Tissue engineering of the gastroesophageal junction.Journal of tissue engineering and regenerative medicine · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kyle W McCrackenDivision of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: kyle.mccracken@childrens.harvard.edu.
James M WellsDivision of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Division of Endocrinology Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Electronic address: james.wells@cchmc.org.
Boston Children's Hospital · USCincinnati Children's Hospital Medical Center · US

Funding

Project-3: Modeling EA/TEF in human organoidsP01HD093363 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Wendy K Chung, Paul scot Kingma · 2017 to 2026
$16.2M
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Organoids as a Model System for Studying Gastrointestinal DiseaseU19AI116491 · NIAID · UNIVERSITY OF CINCINNATI · PI WEISS, ALISON A., WELLS, JAMES M · 2015 to 2019
$4.6M
Investigation of Regional Identity in Human Intestinal Stem CellsU01DK103117 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HELMRATH, MICHAEL A. · 2014 to 2023
$4.0M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Human Endocrine Cell DevelopmentR01DK092456 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI WELLS, JAMES M · 2012 to 2016
$2.3M
Single Cell/RNA-Seq dissection of Human iPS cell development into intestineR01DK098350 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WELLS, JAMES M · 2013 to 2016
$1.3M
Establishment of in vitro and in vivo models of human gastrointestinal organoids with a functional ENSU18EB021780 · NIBIB · CINCINNATI CHILDRENS HOSP MED CTR · PI HELMRATH, MICHAEL A., WELLS, JAMES M · 2015 to 2016
$622k
NIAID NIH HHS U19 AI116491NIBIB NIH HHS U18 EB021780NICHD NIH HHS P01 HD093363NIDDK NIH HHS R01 DK092456NIDDK NIH HHS R01 DK098350NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103117NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

The stomach is a digestive organ that has important roles in human physiology and pathophysiology. The developmental origin of the stomach is the embryonic foregut, which also gives rise a number of other structures. There are several signaling pathways and transcription factors that are known to regulate stomach development at different stages, including foregut patterning, stomach specification, and gastric regionalization. These developmental events have important implications in later homeostasis and disease in the adult stomach. Here we will review the literature that has shaped our current understanding of the molecular mechanisms that coordinate gastric organogenesis. Further we will discuss how developmental paradigms have guided recent efforts to differentiate stomach tissue from pluripotent stem cells.

Indexed as

Embryonic DevelopmentEndodermHumansStomachTranscription FactorsTranscription FactorsAntrumCorpusEndodermForegutFundusStomach

Identifiers

PMID28238948
PMCPMC5474362
OpenAlexW2590072907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.