Evidence map›Paper›PMID 28238533›Full record

ArticleStructure (London, England : 1993)2017

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.

Robert E Powers, Rachelle Gaudet, Marcos Sotomayor

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Usher Syndrome: Genetics of a Human Ciliopathy.International journal of molecular sciences · 2021
    Review
  13. Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. BamA is required for autotransporter secretion.Biochimica et biophysica acta. General subjects · 2020
    Article
  15. Article
  16. Review
  17. Nanomechanics of tip-link cadherins.Scientific reports · 2019
    Article
  18. Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
  20. Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.Cold Spring Harbor perspectives in biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert E PowersDepartment of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA; Biophysics Graduate Program, Harvard University, Boston, MA 02115, USA.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA. Electronic address: gaudet@mcb.harvard.edu.
Marcos SotomayorDepartment of Chemistry and Biochemistry, The Ohio State University, 484 West 12(th) Avenue, Columbus, OH 43210, USA. Electronic address: sotomayor.8@osu.edu.

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
MOLECULAR BASIS OF INHERITED DEAFNESSR01DC002281 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI COREY, DAVID P · 1994 to 2018
$4.4M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKSR00DC012534 · NIDCD · OHIO STATE UNIVERSITY · PI SOTOMAYOR, MARCOS · 2013 to 2015
$745k
FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKSK99DC012534 · NIDCD · HARVARD MEDICAL SCHOOL · PI SOTOMAYOR, MARCOS · 2012 to 2012
$96k
NCRR NIH HHS S10 RR029205NIDCD NIH HHS K99 DC012534NIDCD NIH HHS R00 DC012534NIDCD NIH HHS R01 DC002281NIGMS NIH HHS P41 GM103403NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Tip links of the inner ear are protein filaments essential for hearing and balance. Two atypical cadherins, cadherin-23 and protocadherin-15, interact in a Ca

Indexed as

Amino Acid MotifsBinding SitesCadherin Related ProteinsCadherinsCalciumEar, InnerHumansModels, MolecularPolymorphism, Single NucleotideProtein BindingProtein Structure, TertiaryCadherin Related ProteinsCadherinsCalciumCDHR15, humancadherin superfamilydeafnesshearingmechanotransductionmolecular dynamics simulationtip linkX-ray crystallography

Identifiers

PMID28238533
PMCPMC5363953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.