Evidence map›Paper›PMID 28238483›Full record

ArticleThe Journal of pediatrics2017

Psychological Factors May Play an Important Role in Pediatric Crohn's Disease Symptoms and Disability.

Miranda A L van Tilburg, Robyn Lewis Claar, Joan M Romano, Shelby L Langer, Douglas A Drossman, William E Whitehead, Bisher Abdullah, Rona L Levy

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00679003 (Psychosocial Intervention for Children With IBD), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00679003 nacompletednot on this map

Psychosocial Intervention for Children With IBD

TypeinterventionalSponsorUniversity of WashingtonRan2007 to 2014Enrolled190ConditionsInflammatory Bowel Disease, Crohn's Disease, Ulcerative ColitisArmsSLCBT, ES
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

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  4. Adolescent and caregiver perceptions of addressing mental health in inflammatory bowel disease.Journal of child health care : for professionals working with children in the hospital and community · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miranda A L van TilburgCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC; Campbell University, College of Pharmacy and Health Sciences, Buies Creek, NC. Electronic address: tilburg@med.unc.edu.
Robyn Lewis ClaarCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC.
Joan M RomanoDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA.
Shelby L LangerSchool of Social Work, University of Washington, Seattle, WA.
Douglas A DrossmanCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC.
William E WhiteheadCenter for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC.
Bisher AbdullahPrime Health Clinic, Puyallup, WA.
Rona L LevySchool of Social Work, University of Washington, Seattle, WA.
University of North Carolina at Chapel Hill · USUniversity of Washington · USCampbell University · US

Funding

Parent training to address pediatric functional abdominal painR01HD036069 · NICHD · UNIVERSITY OF WASHINGTON · PI LEVY, RONA L. · 1999 to 2015
$6.4M
Psychosocial Intervention for Children with IBDR01HD050345 · NICHD · UNIVERSITY OF WASHINGTON · PI LEVY, RONA L. · 2007 to 2010
$2.0M
NICHD NIH HHS R01 HD036069NICHD NIH HHS R01 HD050345
6 · The paper itself

Abstract

objectiveTo examine the relative contributions of disease activity and psychological factors to self-reported symptoms and disability in children with Crohn's disease. STUDY

designParticipants (n = 127 children age 8-18 years) completed questionnaires on symptom severity and disability, as well as psychological measures assessing anxiety, depression, pain beliefs and coping. Disease activity was measured by the Pediatric Crohn's Disease Activity Index. Structural equation modeling was used to test the effects of disease activity and psychological factors on symptoms and disability.

resultsIn the hypothesized model predicting symptoms, psychological factors (β = 0.58; P < .001) were significantly associated with disease symptoms but disease activity was not. The model for disability yielded significant associations for both psychological factors (β = 0.75; P < .001) and disease activity (β = 0.61, P < .05).

conclusionCrohn's disease symptoms in children and adolescents are not only driven by disease activity. Coping, anxiety, depression, and cognition of illness are important in the patient-reporting of symptom severity and disability. Physicians need to be aware that symptom self-reporting can be driven by psychological factors and may not always be simply an indicator of disease activity.

trial registrationClinicalTrials.gov: NCT00679003.

Indexed as

Diagnostic Self EvaluationDisability EvaluationSymptom AssessmentAdolescentAnxietyChildCrohn DiseaseDepressionDevelopmental DisabilitiesFemaleHumansMaleanxietycatastrophizingcopingCrohn's diseasedepressiondisease activity

Identifiers

PMID28238483
PMCPMC5407185
OpenAlexW2591547055

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.