ArticleEcotoxicology (London, England)2017
Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum.
Article in Ecotoxicology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 67 citations in OpenAlex.
- Multi-Omics Analysis of Hepatopancreatic Responses to Ammonia Nitrogen Stress in Diploid Pacific Oysters (Animals : an open access journal from MDPI · 2026Article
- Synergistic Effects of Ammonia and Hypoxia Stress on the Transcriptomic Responses of the Razor Clam (Animals : an open access journal from MDPI · 2026Article
- Integrated Analysis of Histophysiological Responses and Transcriptome-Metabolome Mechanisms inAnimals : an open access journal from MDPI · 2026Article
- Dietary Yucca schidigera and Bacillus subtilis enhance growth and immunity while reducing ammonia discharge in Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2025Article
- Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos.Toxics · 2025Article
- Polystyrene Nanomicroplastics Aggravate Ammonia-Induced Neurotoxic Effects in Zebrafish Embryos.Toxics · 2024Article
- Behavioral Variables to Assess the Toxicity of Unionized Ammonia in Aquatic Snails: Integrating Movement and Feeding Parameters.Archives of environmental contamination and toxicology · 2022Article
- Evaluation of benzo[Toxicology reports · 2022Article
- Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa.Scientific reports · 2021Article
- Vital Role ofFrontiers in physiology · 2021Article
- Immunological Responses of Marine Bivalves to Contaminant Exposure: Contribution of the -Omics Approach.Frontiers in immunology · 2021Review
- Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of cathepsin D.Biochemical and biophysical research communications · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia nitrogen has been a potential menace to aquatic animals along the coastline of China. Presently, the toxicological effects of ammonia nitrogen were mainly concentrated on fishes, while little attention has been paid to molluscs. In this study, the clam Ruditapes philippinarum was used as the target animal to investigate the toxic effects of ammonia nitrogen. Our results showed that ammonia exposure could significantly reduce the integrity of lysosomes in a dose-dependent manner. Metabolite analysis revealed that exposure doses and duration time of ammonia nitrogen could affect the variation profiles of gill metabolites. In detail, branched chain amino acids, glutamate, choline and phosphocholine were significantly decreased after a one-day exposure. Inosine and phenylalanine were found significantly increased and ATP was decreased after a three-day exposure. The changes of metabolites implied that metabolisms of muscle element, neurotransmission and cell apoptosis of gill tissues would be affected by ammonia exposure. Such inferences were supported by the diminished muscle element, decreased concentrations of catecholamines and increased apoptosis rates, respectively. Therefore, we take advantage of metabolomics integrated with conventional biological assays to find out that ammonia exposure could cause lysosome instability, metabolic disturbance, aberrant gill structures and changes to neurotransmitters, and would result in mollusk gill dysfunction in feeding, respiration and immunity.
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