ArticleAtherosclerosis2017
The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA).
Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Pooled it
- The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study.PloS one · 2017Trial
- Oxidative balance score as a predictor of MASLD-CVD comorbidity risk and mortality: Insights from traditional and machine learning approaches.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Association between cigarette smoking and carotid intima-media thickness among young Saudi adults: a cross-sectional ultrasonographic study.BMC cardiovascular disorders · 2026Article
- Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.Journal of the American Heart Association · 2026Article
- Article
- Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells.Cell communication and signaling : CCS · 2025Article
- Cardiovascular Disease Risk in South Asians in the Baylor Scott and White Health DILWALE Registry.JACC. Advances · 2024Article
- Advancements in Cardiovascular Disease Research Affected by Smoking.Reviews in cardiovascular medicine · 2024Review
- Neutrophil extracellular traps induced by IL-1β promote endothelial dysfunction and aggravate limb ischemia.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people.Frontiers in cardiovascular medicine · 2023Review
- Investigating the association of traditional and non-traditional tobacco product use with subclinical and clinical cardiovascular disease: The Cross-Cohort Collaboration-Tobacco working group rationale, design, and methodology.Tobacco induced diseases · 2023Article
- Review
- Fetal and Childhood Exposure to Parental Tobacco Smoking and Arterial Health at Age 10 Years.American journal of hypertension · 2022Article
- Effect of heavy cigarette and water pipe smoking on antioxidants and lipids in Sudanese male smokers: a case-control study.African health sciences · 2022Article
- Coronary artery calcium is associated with increased risk for lung and colorectal cancer in men and women: the Multi-Ethnic Study of Atherosclerosis (MESA).European heart journal. Cardiovascular Imaging · 2022Article
- Relation of Cigarette Smoking and Heart Failure in Adults ≥65 Years of Age (From the Cardiovascular Health Study).The American journal of cardiology · 2022Article
- Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study.Journal of the American Heart Association · 2022Article
- Factors associated with stroke among patients with type 2 diabetes mellitus in China: a propensity score matched study.Acta diabetologica · 2021Article
- Systemic circulating inflammatory burden and periodontitis in adolescents.Clinical oral investigations · 2021Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsModern tobacco regulatory science requires an understanding of which biomarkers of cardiovascular injury are most sensitive to cigarette smoking exposure.
methodsWe studied self-reported current smokers from the Multi-Ethnic Study of Atherosclerosis. Smoking intensity was defined by number of cigarettes/day and urinary cotinine levels. Subclinical cardiovascular injury was assessed using markers of inflammation [high-sensitivity C-reactive protein (hsCRP), interleukin 6 & 2 (IL-2 & IL-6), tumor necrosis factor alpha (TNF-α)], thrombosis (fibrinogen, D-dimer, homocysteine), myocardial injury (troponin T; TnT), endothelial damage (albumin: creatinine ratio), and vascular function [aortic & carotid distensibility, flow-mediated dilation (FMD)]. Biomarkers were modeled as absolute and percent change using multivariable-adjusted linear regression models adjusted for cardiovascular risk factors and smoking duration.
resultsAmong 843 current smokers, mean age was 58 (9) years, 53% were men, 39% were African American, mean number of cigarettes per day was 13 (10), and median smoking duration was 39 (15) years. Cigarette count was significantly associated with higher hsCRP, IL-6 and fibrinogen (β coefficients: 0.013, 0.011, 0.60 respectively), while ln-transformed cotinine was associated with the same biomarkers (β coefficients: 0.12, 0.04, 5.3 respectively) and inversely associated with aortic distensibility (β coefficient: -0.13). There was a limited association between smoking intensity and homocysteine, D-dimer, and albumin:creatinine ratio in partially adjusted models only, while there was no association with IL-2, TNF-α, carotid distensibility, FMD, or TnT in any model. In percent change analyses, relationships were strongest with hsCRP.
conclusionsSmoking intensity was associated with early biomarkers of CVD, particularly, markers of systemic inflammation. Of these, hsCRP may be the most sensitive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.