Evidence map›Paper›PMID 28237890›Full record

ArticleInternational journal for parasitology2017

Experimental and modelling investigations of Opisthorchis viverrini miracidia transmission over time and across temperatures: implications for control.

Pierre Echaubard, Tomas León, Kulwadee Suwanatrai, Jukkrid Chaiyos, Christina S Kim, Frank F Mallory, Sasithorn Kaewkes, Robert C Spear, Banchob Sripa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The impact of climate change on neglected tropical diseases: a systematic review.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pierre EchaubardGlobal Health Asia, Integrative Education and Research Programme, Faculty of Public Health, Mahidol University, Bangkok, Thailand; WHO Collaborative Center for Research and Control of Opisthorchiasis, Tropical Disease Research Laboratory, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Biology, Laurentian University, Sudbury, Ontario P3E 2C6, Canada. Electronic address: pn_echaubard@laurentian.ca.
Tomas LeónWHO Collaborative Center for Research and Control of Opisthorchiasis, Tropical Disease Research Laboratory, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; School of Public Health, University of California, Berkeley, CA 94720, USA.
Kulwadee SuwanatraiDepartment of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand.
Jukkrid ChaiyosDepartment of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand.
Christina S KimWHO Collaborative Center for Research and Control of Opisthorchiasis, Tropical Disease Research Laboratory, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Frank F MalloryDepartment of Biology, Laurentian University, Sudbury, Ontario P3E 2C6, Canada.
Sasithorn KaewkesDepartment of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand.
Robert C SpearSchool of Public Health, University of California, Berkeley, CA 94720, USA.
Banchob SripaWHO Collaborative Center for Research and Control of Opisthorchiasis, Tropical Disease Research Laboratory, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Liver Fluke and Cholangiocarcinoma Research Center, Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: banchob@kku.ac.th.

Funding

Pathogenesis of Opisthorchiasis induced persistent periductal fibrosis and CCAP50AI098639 · NIAID · KHON KAEN UNIVERSITY · PI SRIPA, BANCHOB · 2012 to 2016
$1.6M
Transmission pathways of the food-borne carcinogen Opisthorchis viverriniR21AI104513 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SPEAR, ROBERT C · 2014 to 2015
$421k
NIAID NIH HHS P50 AI098639NIAID NIH HHS R21 AI104513
6 · The paper itself

Abstract

Transmissibility is a significant factor in parasite fitness. The rate and magnitude of parasite transmission affect prevalence and infection intensity in individual hosts and are influenced by environmental factors. In this context, the objectives of this study were: (i) to experimentally assess Opisthorchis viverrini miracidia survival and infectivity over time and across temperatures; and (ii) to combine these experimental results with environmental data to build a key component of a transmission model, identifying seasonal windows of transmission risk in hyper-endemic northeastern Thailand. Five replicates of 50 O. viverrini eggs were randomly distributed and maintained under four temperature conditions (25°C, 30°C, 35°C, 40°C). Microscopic observations were performed on all experimental units over a period of 3months to record miracidia motility and mortality trends. Six infection trials were also conducted to assess infectivity of miracidia over time and across temperatures, using observations of egg hatching success and infection rates. Upon completion of experiments, data were integrated into a transmission model to create a transmission risk index and to simulate seasonal transmission risk. Miracidia survival rate and motility decreased steadily with 50% mortality observed after 2weeks. Hatching and infection success also decreased significantly after 3weeks. Temperatures over 30°C were associated with increased mortality and decreased infectivity. When incorporating local environmental parameters into our model, we observed low transmission risk during the dry season and increasing transmission risk at the onset of the rainy season, culminating with the highest risk in September. We believe that our results provide the first estimates of O. viverrini miracidia survival and transmission potential under variable temperature conditions and suggest that high temperature treatment (>40°C) of fecal waste could be an efficient control strategy.

Indexed as

AnimalsClimateComputer SimulationCricetinaeFish DiseasesFishesHost-Parasite InteractionsMaleMesocricetusModels, BiologicalOpisthorchiasisOpisthorchisPrevalenceSeasonsSnailsThailandBithynia siamensis goniomphalosHost–parasiteLiver flukeTemperature-dependentThailandTransmission dynamics

Identifiers

PMID28237890
PMCPMC5525327

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.