Evidence map›Paper›PMID 28237836›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2017

Inhibitory Receptors Induced by VSV Viroimmunotherapy Are Not Necessarily Targets for Improving Treatment Efficacy.

Kevin G Shim, Shane Zaidi, Jill Thompson, Tim Kottke, Laura Evgin, Karishma R Rajani, Matthew Schuelke, Christopher B Driscoll, Amanda Huff, Jose S Pulido and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Synergy betweenJournal for immunotherapy of cancer · 2021
    Article
  7. Article
  8. Article
  9. Oncolytic Viruses: Priming Time for Cancer Immunotherapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
    Article
  14. Article
  15. Oncolytic Virotherapy: A Contest between Apples and Oranges.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Review
  16. Partners in Crime: Combining Oncolytic Viroimmunotherapy with Other Therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kevin G ShimDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA.
Shane ZaidiTargeted Therapy Laboratory, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JJ, UK.
Jill ThompsonDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Tim KottkeDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Laura EvginDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Karishma R RajaniDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Matthew SchuelkeDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA.
Christopher B DriscollDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Amanda HuffDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jose S PulidoDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
Richard G VileDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: vile.richard@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USInstitute of Cancer Research · GBWinnMed · US

Funding

Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI BALLMAN, KARLA V. · 2004 to 2015
$22.5M
Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
Enhancing Therapy of Primary and Recurrent Tumors With Systemic Oncolytic VirusR01CA175386 · NCI · MAYO CLINIC ROCHESTER · PI VILE, RICHARD G. · 2014 to 2018
$1.3M
Improving Efficacy and Safety of VSV Immunotherapy for Metastatic MelanomaF30CA199962 · NCI · MAYO CLINIC ROCHESTER · PI SHIM, KEVIN G · 2016 to 2019
$147k
Cancer Research UKNCI NIH HHS F30 CA199962NCI NIH HHS P50 CA108961NCI NIH HHS R01 CA175386NIGMS NIH HHS T32 GM065841
6 · The paper itself

Abstract

Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen activates antigen-specific adoptively transferred T cells (adoptive cell therapy, ACT) in vivo to generate effective therapy. The overall goal of this study was to phenotypically characterize the immune response to VSV+ACT therapy and use the information gained to rationally improve combination therapy. We observed rapid expansion of blood CD8

Indexed as

Adoptive TransferImmunotherapyAnimalsAntigens, NeoplasmDisease Models, AnimalFemaleGenetic VectorsHepatitis A Virus Cellular Receptor 2Immunologic MemoryMelanoma, ExperimentalMiceMortalityNeoplasm MetastasisProgrammed Cell Death 1 ReceptorT-Lymphocyte SubsetsTreatment OutcomeAntigens, NeoplasmHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Programmed Cell Death 1 Receptorcheckpoint inhibitorsoncolytic virotherapytumor therapy

Identifiers

PMID28237836
PMCPMC5383647
OpenAlexW2590350007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.