Evidence map›Paper›PMID 28237741›Full record

ArticleNeuropsychologia2017

Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.

N C van Wouwe, S Pallavaram, F T Phibbs, D Martinez-Ramirez, J S Neimat, B M Dawant, P F D'Haese, K E Kanoff, W P M van den Wildenberg, M S Okun and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  13. Effects of deep brain stimulation target on the activation and suppression of action impulses.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Article
  14. Review
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  20. New pharmacological and neuromodulation approaches for impulsive-compulsive behaviors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

N C van WouweDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: nelleke.van.wouwe@vanderbilt.edu.
S PallavaramDepartment of Engineering, Vanderbilt University, Nashville, TN, USA.
F T PhibbsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
D Martinez-RamirezDepartment of Neurology, University of Florida Medical Center, Gainesville, Florida, USA.
J S NeimatDepartment of Neurosurgery, University of Louisville Medical Center, Louisville, KY, USA.
B M DawantDepartment of Engineering, Vanderbilt University, Nashville, TN, USA.
P F D'HaeseDepartment of Engineering, Vanderbilt University, Nashville, TN, USA.
K E KanoffDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
W P M van den WildenbergCognitive Science Center Amsterdam and Psychology Department, University of Amsterdam, Amsterdam, The Netherlands.
M S OkunDepartment of Neurology, University of Florida Medical Center, Gainesville, Florida, USA.
S A WylieDepartment of Neurosurgery, University of Louisville Medical Center, Louisville, KY, USA.
Vanderbilt University · USVanderbilt University Medical Center · USUniversity of Florida · USUniversity of Louisville · USUniversity of Amsterdam · NL

Funding

Computer-Assisted functional neurosurgeryR01EB006136 · NIBIB · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M. · 2006 to 2013
$4.0M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
THE HUMAN THALAMOCORTICAL NETWORK IN TOURETTE SYNDROMER01NS096008 · NINDS · UNIVERSITY OF FLORIDA · PI GUNDUZ, AYSEGUL, OKUN, MICHAEL S · 2016 to 2020
$1.8M
Neurocognitive Mechanisms of Inhibition Deficits in Parkinson's DiseaseK23AG028750 · NIA · VANDERBILT UNIVERSITY · PI WYLIE, SCOTT A · 2009 to 2013
$791k
The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional ProcessingR21NS070136 · NINDS · VANDERBILT UNIVERSITY · PI FOLLEY, BRADLEY SCOTT, NEIMAT, JOSEPH S · 2011 to 2012
$423k
NIA NIH HHS K23 AG028750NIBIB NIH HHS R01 EB006136NINDS NIH HHS R01 NS095291NINDS NIH HHS R01 NS096008NINDS NIH HHS R21 NS070136NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Frontal-basal ganglia circuitry dysfunction caused by Parkinson's disease impairs important executive cognitive processes, such as the ability to inhibit impulsive action tendencies. Subthalamic Nucleus Deep Brain Stimulation in Parkinson's disease improves the reactive inhibition of impulsive actions that interfere with goal-directed behavior. An unresolved question is whether this effect depends on stimulation of a particular Subthalamic Nucleus subregion. The current study aimed to 1) replicate previous findings and additionally investigate the effect of chronic versus acute Subthalamic Nucleus stimulation on inhibitory control in Parkinson's disease patients off dopaminergic medication 2) test whether stimulating Subthalamic Nucleus subregions differentially modulate proactive response control and the proficiency of reactive inhibitory control. In the first experiment, twelve Parkinson's disease patients completed three sessions of the Simon task, Off Deep brain stimulation and medication, on acute Deep Brain Stimulation and on chronic Deep Brain Stimulation. Experiment 2 consisted of 11 Parkinson's disease patients with Subthalamic Nucleus Deep Brain Stimulation (off medication) who completed two testing sessions involving of a Simon task either with stimulation of the dorsal or the ventral contact in the Subthalamic Nucleus. Our findings show that Deep Brain Stimulation improves reactive inhibitory control, regardless of medication and regardless of whether it concerns chronic or acute Subthalamic Nucleus stimulation. More importantly, selective stimulation of dorsal and ventral subregions of the Subthalamic Nucleus indicates that especially the dorsal Subthalamic Nucleus circuitries are crucial for modulating the reactive inhibitory control of motor actions.

Indexed as

Deep Brain StimulationInhibition, PsychologicalAntiparkinson AgentsDopamine AgentsFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityNeuropsychological TestsParkinson DiseaseReaction TimeSubthalamic NucleusAntiparkinson AgentsDopamine AgentsInhibititory controlParkinson's diseaseSimon taskSubthalamic nucleus deep brain stimulationSubthalamic nucleus subregions

Identifiers

PMID28237741
PMCPMC5493526
OpenAlexW2591558431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.