ArticleBiological psychiatry2017
Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Amylin: A Multi-Functional Pancreatic Hormone-A Review.Diabetes, obesity & metabolism · 2026Review
- Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner.Translational psychiatry · 2026Article
- The story of amylin: from physiology to therapy.Nature metabolism · 2026Review
- Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.Physiology & behavior · 2025Article
- From the pancreas to the amygdala: New brain area critical for ingestive and motivated behavior control exerted by amylin.iScience · 2025Article
- The alpha-7 nicotinic acetylcholine receptor agonist PHA-543613 reduces food intake in male rats.Pharmacology, biochemistry, and behavior · 2024Article
- Construction and Identification of a Breast Bioreactor for Human-Derived Hypoglycemic Protein Amylin.Life (Basel, Switzerland) · 2024Article
- Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights.Physiology & behavior · 2023Review
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors.Frontiers in pharmacology · 2022Article
- Insight into the role of the gut-brain axis in alcohol-related responses: Emphasis on GLP-1, amylin, and ghrelin.Frontiers in psychiatry · 2022Review
- Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.Biomolecules · 2021Review
- The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections.Nutrients · 2021Article
- Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice.Frontiers in pharmacology · 2021Article
- Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice.Psychopharmacology · 2020Article
- Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway.Biological psychiatry · 2020Article
- Individual Differences in Behavioral Responses to Palatable Food or to Cholecystokinin Predict Subsequent Diet-Induced Obesity.Obesity (Silver Spring, Md.) · 2019Article
- An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents.Addiction biology · 2019Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe pancreatic- and brain-derived hormone amylin promotes negative energy balance and is receiving increasing attention as a promising obesity therapeutic. However, the neurobiological substrates mediating amylin's effects are not fully characterized. We postulated that amylin acts in the lateral dorsal tegmental nucleus (LDTg), an understudied neural processing hub for reward and homeostatic feeding signals.
methodsWe used immunohistochemical and quantitative polymerase chain reaction analyses to examine expression of the amylin receptor complex in rat LDTg tissue. Behavioral experiments were performed to examine the mechanisms underlying the hypophagic effects of amylin receptor activation in the LDTg.
resultsImmunohistochemical and quantitative polymerase chain reaction analyses show expression of the amylin receptor complex in the LDTg. Activation of LDTg amylin receptors by the agonist salmon calcitonin dose-dependently reduces body weight, food intake, and motivated feeding behaviors. Acute pharmacological studies and longer-term adeno-associated viral knockdown experiments indicate that LDTg amylin receptor signaling is physiologically and potentially preclinically relevant for energy balance control. Finally, immunohistochemical data indicate that LDTg amylin receptors are expressed on gamma-aminobutyric acidergic neurons, and behavioral results suggest that local gamma-aminobutyric acid receptor signaling mediates the hypophagia after LDTg amylin receptor activation.
conclusionsThese findings identify the LDTg as a novel nucleus with therapeutic potential in mediating amylin's effects on energy balance through gamma-aminobutyric acid receptor signaling.
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