Evidence map›Paper›PMID 28237458›Full record

ArticleBiological psychiatry2017

Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.

Matthew D Albaugh, Catherine Orr, Bader Chaarani, Robert R Althoff, Nicholas Allgaier, Nicholas D'Alberto, Kelsey Hudson, Scott Mackey, Philip A Spechler, Tobias Banaschewski and 29 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 13 institutions in 7 countries.

Matthew D AlbaughDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont. Electronic address: malbaugh@uvm.edu.
Catherine OrrDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Bader ChaaraniDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Robert R AlthoffDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Nicholas AllgaierDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Nicholas D'AlbertoDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Kelsey HudsonDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Scott MackeyDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Philip A SpechlerDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin.
Uli BrombergUniversity Medical Center Hamburg-Eppendorf, Hamburg.
Christian BüchelUniversity Medical Center Hamburg-Eppendorf, Hamburg.
Anna CattrellMedical Research Council Social, Genetic and Developmental Psychiatry Centre, University of Nottingham, Nottingham, United Kingdom.
Patricia J ConrodDepartment of Psychological Medicine and Psychiatry, University of Nottingham, Nottingham, United Kingdom; Department of Psychiatry, Université de Montréal, Centre Hospitalier Universitaire Sainte-Justine Hospital, Montreal, Quebec.
Sylvane DesrivièresMedical Research Council Social, Genetic and Developmental Psychiatry Centre, University of Nottingham, Nottingham, United Kingdom.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Fac ulty Mannheim, Heidelberg University, Mannheim.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique, CEA Saclay Center, Paris, France.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Hamburg.
Robert GoodmanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, University of Nottingham, Nottingham, United Kingdom.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
Yvonne GrimmerDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Fac ulty Mannheim, Heidelberg University, Mannheim.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin.
Viola KappelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale Unit 1000 Neuroimaging and Psychiatry, University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale Unit 1000 Neuroimaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France; Department of Adolescent Psychopathology and Medicine, Maison De Solenn, Cochin Hospital, Paris, France.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Fac ulty Mannheim, Heidelberg University, Mannheim.
Dimitri Papadopoulos OrfanosNeurospin, Commissariat à l'Energie Atomique, CEA Saclay Center, Paris, France.
Jani PenttilaMedical School, University of Tampere, Tampere, Finland.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim.
Tomáš PausRotman Research Institute, Baycrest, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Maren StruveDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Fac ulty Mannheim, Heidelberg University, Mannheim.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin.
Robert WhelanDepartment of Psychology, University College Dublin, Dublin.
Gunter SchumannMedical Research Council Social, Genetic and Developmental Psychiatry Centre, University of Nottingham, Nottingham, United Kingdom.
Hugh GaravanDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
Alexandra S PotterDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont.
University of Vermont · USHeidelberg University · DEUniversity of Nottingham · GBCharité - Universitätsmedizin Berlin · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRUniversität Hamburg · DEPhysikalisch-Technische Bundesanstalt · DETampere University · FITechnische Universität Dresden · DETrinity College Dublin · IEUniversity College Dublin · IEUniversity of Toronto · CA

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SIGMON, STACEY C · 2013 to 2022
$21.3M
Vermont Center on Tobacco Regulatory ScienceP50DA036114 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HIGGINS, STEPHEN T · 2013 to 2017
$19.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
NIBIB NIH HHS U54 EB020403NIDA NIH HHS P50 DA036114NIGMS NIH HHS P20 GM103644NIMH NIH HHS L40 MH108486NIMH NIH HHS R01 MH085772Wellcome Trust
6 · The paper itself

Abstract

backgroundNeuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression.

methodsPsychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated.

resultsParent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology.

conclusionsThis is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityChildFemaleHumansMalePrefrontal CortexReaction TimeAttention-deficit/hyperactivity disorderInattentionMulti-informantNeuroimagingReaction time variabilityVentromedial prefrontal cortex

Identifiers

PMID28237458
PMCPMC5509516
OpenAlexW2572261981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.