Evidence map›Paper›PMID 28237085›Full record

Trial reportProstaglandins, leukotrienes, and essential fatty acids2017

Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials.

Brietta M Oaks, Rebecca R Young, Seth Adu-Afarwuah, Ulla Ashorn, Kristina H Jackson, Anna Lartey, Kenneth Maleta, Harriet Okronipa, John Sadalaki, Lacey M Baldiviez and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Prostaglandins, leukotrienes, and essential fatty acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Pooled it
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  12. Review
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  17. Importance of Bioactive Substances in Sheep's Milk in Human Health.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brietta M OaksProgram in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA. Electronic address: boaks@ucdavis.edu.
Rebecca R YoungProgram in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Ghana.
Ulla AshornCenter for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
Kristina H JacksonOmegaQuant Analytics, LLC, Sioux Falls, SD, USA.
Anna LarteyDepartment of Nutrition and Food Science, University of Ghana, Legon, Ghana.
Kenneth MaletaUniversity of Malawi College of Medicine, Department of Community Health, Blantyre, Malawi.
Harriet OkronipaProgram in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.
John SadalakiUniversity of Malawi College of Medicine, Department of Community Health, Blantyre, Malawi.
Lacey M BaldiviezUSDA, ARS Western Human Nutrition Research Center, Davis, CA, USA.
Setti Shahab-FerdowsUSDA, ARS Western Human Nutrition Research Center, Davis, CA, USA.
Per AshornCenter for Child Health Research, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California, 3135 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids (wt%) at 6 months postpartum in a subsample of women enrolled in a randomized controlled trial studying the effects of SQ-LNS on birth outcomes and child growth. Women≤20 wk gestation in Ghana (n=1,320) and Malawi (n=1,391) were assigned to receive daily either: 1) iron-folic acid (pregnancy); 2) multiple micronutrients (pregnancy and lactation); or 3) SQ-LNS (pregnancy and lactation). At 36 wk, plasma ALA levels were higher in those receiving SQ-LNS. SQ-LNS increased breast milk ALA in Ghana but not Malawi. There was no effect on plasma lipids or other selected fatty acids. SQ-LNS may impact plasma and breast milk ALA levels depending on the population.

Indexed as

Adultalpha-Linolenic AcidDietary SupplementsFatty AcidsFemaleFolic AcidGestational AgeGhanaHumansLactationLinoleic AcidMalawiMaternal Nutritional Physiological PhenomenaMicronutrientsMilk, HumanNutritional Statusalpha-Linolenic AcidFatty AcidsFolic AcidLinoleic AcidMicronutrientsCholesterolLactationLipidsOmega-3 fatty acidsPregnancySupplementation

Identifiers

PMID28237085
PMCPMC5338685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.