ArticleTuberculosis (Edinburgh, Scotland)2017
Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection?
Article in Tuberculosis (Edinburgh, Scotland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Treatment and recurrence on re-treatment tuberculosis patients: a randomized clinical trial and 7-year perspective cohort study in China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Trial
- Sputum-negative pulmonary tuberculosis in Shanghai, China: notification, clinical characteristics and outcomes.BMC infectious diseases · 2026Article
- Factors Involved in Tuberculosis Recurrence in a Low-incidence Setting; Reactivation Predominates Over Reinfection in a 30-year Surveillance Study.Open forum infectious diseases · 2026Article
- Drug resistance characteristics and risk factors in patients with retreated pulmonary tuberculosis: a 5-year retrospective study in Suzhou, China.Frontiers in public health · 2026Article
- Data mining technique for identifying mortality patterns in a pulmonary tuberculosis cohort.Cadernos de saude publica · 2026Article
- Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus.Nature communications · 2025Article
- Time to reoccurrence of tuberculosis and its predictors among adult HIV/AIDS patients on ART at public hospitals in East and Horro Guduru Wollega zones, West Ethiopia: a retrospective cohort study.BMC public health · 2025Article
- Endogenous reactivation cases identified by whole genome sequencing ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Transmissibility and control of tuberculosis in school outbreaks: a modeling study based on four outbreaks in China.BMC infectious diseases · 2024Article
- Identifying risk factors for recurrent multidrug resistant tuberculosis based on patient's record data from 2016 to 2021: retrospective study.Scientific reports · 2024Article
- CD4Immunity · 2024Article
- The impact of diabetes mellitus on tuberculosis recurrence in Eastern China: a retrospective cohort study.BMC public health · 2024Article
- Recurrent Pulmonary Tuberculosis in China, 2005 to 2021.JAMA network open · 2024Article
- Antibiotic treatment modestly reduces protection againstInfection and immunity · 2024Article
- Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques.bioRxiv : the preprint server for biology · 2024Article
- CD4bioRxiv : the preprint server for biology · 2023Article
- Discrepancy in the transmissibility of multidrug-resistantEmerging microbes & infections · 2023Article
- Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencing.Frontiers in microbiology · 2023Article
- Long-term economic evaluation of the recombinantFrontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Recurrent tuberculosis is an important indicator of the effectiveness of tuberculosis control and can occur by relapse or exogenous reinfection. We conducted a retrospective cohort study on all bacteriologically confirmed tuberculosis cases that were successfully treated between 2000 and 2012 in Shanghai, an urban area with a high number but a low prevalence rate of tuberculosis cases and a low prevalence of HIV infection. Genotyping the Mycobacterium tuberculosis from clinical isolates was used to distinguish between relapse and reinfection. In total, 5.3% (710/13,417) of successfully treated cases had a recurrence, a rate of 7.55 (95% CI 7.01-8.13) episodes per 1000 person-years, more than 18 times the rate of tuberculosis in the general population. Patients who were male, age 30-59, retreatment cases, had cavitation, diabetes, drug-resistant or multidrug-resistant tuberculosis in their initial episode of tuberculosis, were at high risk for a recurrence. Among 141 recurrent cases that had paired isolates, 59 (41.8%) had different genotypes, indicating reinfection with a different strain. Patients who completed treatment were still at high risk of another episode of tuberculosis and exogenous reinfection contributed a significant proportion of the recurrent tuberculosis cases. Targeted control strategies are needed to prevent new tuberculosis infections in this setting.
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