Evidence map›Paper›PMID 28236964›Full record

ReviewCurrent topics in developmental biology2017

WNK Kinases in Development and Disease.

Aylin R Rodan, Andreas Jenny

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Constituents ofMolecules (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Germline mutations inJournal of medical genetics · 2023
    Article
  14. Experimental and therapeutic medicine · 2023
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Aylin R RodanUT Southwestern, Dallas, TX, United States. Electronic address: aylin.rodan@hsc.utah.edu.
Andreas JennyAlbert Einstein College of Medicine, New York, NY, United States. Electronic address: andreas.jenny@einstein.yu.edu.
Albert Einstein College of Medicine · USThe University of Texas Southwestern Medical Center · US

Funding

Special Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI WOLKOFF, ALLAN W · 1989 to 2018
$22.9M
WNK KINASES IN DEVELOPMENTR01GM115646 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JENNY, ANDREAS · 2016 to 2019
$1.5M
WNK & SPAK/OSR1 regulation of SLC12 cotransporters in DrosophilaK08DK091316 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2011 to 2015
$727k
Probing intracellular Cl- in a WNK signaling-dependent transporting epitheliumR03DK106350 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2015 to 2016
$156k
NIDDK NIH HHS K08 DK091316NIDDK NIH HHS P30 DK041296NIDDK NIH HHS R03 DK106350NIGMS NIH HHS R01 GM115646
6 · The paper itself

Abstract

WNK (With-No-Lysine (K)) kinases are serine-threonine kinases characterized by an atypical placement of a catalytic lysine within the kinase domain. Mutations in human WNK1 or WNK4 cause an autosomal dominant syndrome of hypertension and hyperkalemia, reflecting the fact that WNK kinases are critical regulators of renal ion transport processes. Here, the role of WNKs in the regulation of ion transport processes in vertebrate and invertebrate renal function, cellular and organismal osmoregulation, and cell migration and cerebral edema will be reviewed, along with emerging literature demonstrating roles for WNKs in cardiovascular and neural development, Wnt signaling, and cancer. Conserved roles for these kinases across phyla are emphasized.

Indexed as

DiseaseEmbryonic DevelopmentAmino Acid SequenceAnimalsHumansModels, BiologicalNeoplasmsProtein Serine-Threonine KinasesSignal TransductionProtein Serine-Threonine KinasesBlood pressureC. elegansDrosophilaExcretory canalKidneyLhx8Malpighian tubuleMo25/Cab39SPAK/OSR1Wnt signalingZebrafish

Identifiers

PMID28236964
PMCPMC5329892
OpenAlexW2526278979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.