Evidence map›Paper›PMID 28236779›Full record

ReviewCurrent opinion in neurobiology2017

MAGUKs: multifaceted synaptic organizers.

Sehoon Won, Jon M Levy, Roger A Nicoll, Katherine W Roche

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  20. Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sehoon WonReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States.
Jon M LevyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States.
Roger A NicollDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, United States; Department of Physiology, University of California, San Francisco, CA 94158, United States.
Katherine W RocheReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: rochek@ninds.nih.gov.

Funding

Subunit-Specific Regulation Of Glutamate ReceptorsZIANS002994 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2009 to 2025
$30.0M
NEUROTRANSMITTER EFFECTS ON LOCAL NEURONAL CIRCUITSR37MH038256 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 1987 to 2016
$9.0M
Synaptic Glutamate Receptor Trafficking.R01MH080379 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 2007 to 2016
$5.3M
Subunit-Specific Regulation Of Glutamate ReceptorsZ01NS002994 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE W · 2002 to 2008
$2.8M
Intramural NIH HHS Z01 NS002994NIMH NIH HHS R01 MH080379NIMH NIH HHS R37 MH038256
6 · The paper itself

Abstract

The PSD-95 family of proteins, known as MAGUKs, have long been recognized to be central building blocks of the PSD. They are categorized as scaffolding proteins, which link surface-expressed receptors to the intracellular signaling molecules. Although the four members of the PSD-95 family (PSD-95, PSD-93, SAP102, and SAP97) have many shared roles in regulating synaptic function, recent studies have begun to delineate specific binding partners and roles in plasticity. In the current review, we will highlight the conserved and unique roles of these proteins.

Indexed as

Disks Large Homolog 4 ProteinGuanylate KinasesHumansNerve Tissue ProteinsSignal TransductionSynapsesDisks Large Homolog 4 ProteinGuanylate KinasesNerve Tissue Proteins

Identifiers

PMID28236779
PMCPMC5447471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.