ArticleRedox biology2017
Oxidative stress, metabolomics profiling, and mechanism of local anesthetic induced cell death in yeast.
Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Article
- Effect of lidocaine on cognitively impaired rats: Anti-inflammatory and antioxidant mechanisms in combination with CRMP2 antiphosphorylation.Immunity, inflammation and disease · 2023Article
- Farnesol as an antifungal agent: comparisons amongFrontiers in physiology · 2023Article
- Comparative Metabolomics Study of the Impact of Articaine and Lidocaine on the Metabolism of SH-SY5Y Neuronal Cells.Metabolites · 2022Article
- Oxidative Stress and Autophagy Are Important Processes in Post Ripeness and Brown Film Formation in Mycelium ofFrontiers in microbiology · 2022Article
- Precursor Quantitation Methods for Next Generation Food Production.Frontiers in bioengineering and biotechnology · 2022Review
- Metabolomic Impact of Lidocaine on a Triple Negative Breast Cancer Cell Line.Frontiers in pharmacology · 2022Article
- Heat stress in macrofungi: effects and response mechanisms.Applied microbiology and biotechnology · 2021Review
- Trehalose alleviates high-temperature stress in Pleurotus ostreatus by affecting central carbon metabolism.Microbial cell factories · 2021Article
- Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress.Aging · 2020Article
- Article
- Aphid-Responsive Defense Networks in Hybrid Switchgrass.Frontiers in plant science · 2020Article
- Metabolic Response ofFrontiers in microbiology · 2019Article
- Lipopolysaccharide induces human olfactory ensheathing glial apoptosis by promoting mitochondrial dysfunction and activating the JNK-Bnip3-Bax pathway.Cell stress & chaperones · 2019Article
- Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways.Cell stress & chaperones · 2018Article
- Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.Redox biology · 2018Article
- ER-Mitochondria Microdomains in Cardiac Ischemia-Reperfusion Injury: A Fresh Perspective.Frontiers in physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations, and genetics leading to the clinically observed adverse effects have not been temporally characterized. To study alterations that may lead to these undesirable effects, Saccharomyces cerevisiae grown on aerobic carbon sources to stationary phase was assessed over 6h. Exposure of an LC
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.