ArticleTranslational research : the journal of laboratory and clinical medicine2017
Procoagulant extracellular vesicles in amniotic fluid.
Article in Translational research : the journal of laboratory and clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- A Beginner's Guide to Study the Role of Extracellular Vesicles in Coagulation.Journal of extracellular biology · 2026Review
- Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics.Journal of extracellular biology · 2026Review
- Analysis of immune-related biomarkers in amniotic fluid embolism by sequencing data and bioinformatics.BMC pregnancy and childbirth · 2025Article
- MUW researcher of the month: Dr.in Carla Tripisciano und Ap. Prof. PD Dr. Johannes Thaler.Wiener klinische Wochenschrift · 2025Article
- Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans.Research and practice in thrombosis and haemostasis · 2025Article
- Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles.Journal of translational medicine · 2024Review
- Extracellular vesicles as markers and mediators of pregnancy complications: gestational diabetes, pre-eclampsia, preterm birth and fetal growth restriction.The Journal of physiology · 2023Review
- The Effect of Extracellular Vesicles on Thrombosis.Journal of cardiovascular translational research · 2023Review
- Feto-placental Unit: From Development to Function.Advances in experimental medicine and biology · 2023Review
- Extracellular vesicles from amniotic fluid, milk, saliva, and urine expose complexes of tissue factor and activated factor VII.Journal of thrombosis and haemostasis : JTH · 2022Article
- Procoagulant Activity in Amniotic Fluid Is Associated with Fetal-Derived Extracellular Vesicles.Current issues in molecular biology · 2022Article
- The role of extracellular vesicles in animal reproduction and diseases.Journal of animal science and biotechnology · 2022Review
- Intraperitoneal Activation of Coagulation and Fibrinolysis in Patients with Cirrhosis and Ascites.Thrombosis and haemostasis · 2022Article
- Extracellular Vesicles in Human Milk.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Human milk triggers coagulation via tissue factor-exposing extracellular vesicles.Blood advances · 2020Article
- Article
- The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers.Molecular cancer · 2019Review
- Salivary tissue factor induces thrombin generation in a diurnal rhythm.Research and practice in thrombosis and haemostasis · 2018Article
- Impact of fetal maceration grade on risk of maternal disseminated intravascular coagulation after intrauterine fetal death - A retrospective cohort study.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Embolization of amniotic fluid (AF) into the blood circulation leads to disseminated intravascular coagulation (DIC). Procoagulant phosphatidylserine (PS)- and tissue factor (TF)-exposing extracellular vesicles (EVs) might play an important role in AF embolism-induced DIC. It was the aim of the present study to perform analyses of the procoagulant properties of AF with a panel of functional coagulation assays and flow cytometry. We applied a prothrombinase assay (that quantifies PS exposure on EVs), an EV-associated TF activity assay, a fibrin generation assay, a thrombin generation assay, a whole blood clotting model, and flow cytometry in AF and control plasma. We found that PS exposure on EVs was 21-fold increased in AF compared with plasma. Also, EV-associated TF activity was highly increased in AF compared with plasma. AF-derived EVs activated the blood coagulation cascade via PS and TF in the fibrin and thrombin generation assays. In a whole blood clotting model, AF-derived EVs significantly shortened the clotting time from 734 ± 139 seconds in the presence to 232 ± 139 seconds in the absence of an anti-TF antibody. The contact activation pathway via factor XII (FXII) was not affected. Applying flow cytometry, a subpopulation of PS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.