ArticleBrain pathology (Zurich, Switzerland)2017
Review of xanthomatous lesions of the sella.
Article in Brain pathology (Zurich, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Are Sellar Xanthogranulomas the Climax of a Spectrum of Secondary Inflammatory Reactions to Various Sellar Lesions?NeuroSci · 2026Article
- Xanthomatous hypophysitis with optic chiasm edema: First documented clinical case.Radiology case reports · 2026Article
- Pituitary Xanthogranuloma Causing Sellar Mass in 2 Children With Hypopituitarism and Elevated Inflammatory Markers.JCEM case reports · 2025Article
- Mimickers of pituitary tumors.Neuro-oncology advances · 2025Article
- Comparison of clinical and radiological characteristics of inflammatory and non-inflammatory Rathke cleft cysts.Japanese journal of radiology · 2025Article
- Secondary xanthogranulomatous hypophysitis mimicking a pituitary macroadenoma: a case report.The Journal of international medical research · 2024Article
- Inflammatory and Infectious Disorders in Endocrine Pathology.Endocrine pathology · 2023Review
- Neuroimaging of hypophysitis: etiologies and imaging mimics.Japanese journal of radiology · 2023Review
- Pituitary adenoma associated with xanthogranuloma.Radiology case reports · 2023Article
- Sellar xanthogranuloma as a diagnostic challenge: a report on five cases.Frontiers in neuroscience · 2023Article
- Endoscopic Endonasal Surgery for Uncommon Pathologies of the Sellar and Parasellar Regions.Advances and technical standards in neurosurgery · 2023Review
- Successful immunomodulatory treatment for recurrent xanthogranulomatous hypophysitis in an adolescent: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity.Journal of personalized medicine · 2022Review
- Sellar xanthogranuloma: A diagnostic challenge.Surgical neurology international · 2022Article
- Xanthomatous Hypophysitis Secondary to a Ruptured Rathke's Cleft Cyst: A Case Report.Brain tumor research and treatment · 2022Article
- Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.The Journal of clinical endocrinology and metabolism · 2022Review
- Xanthogranuloma of the sellar region: A case report.Medicine · 2020Article
- Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation.Best practice & research. Clinical endocrinology & metabolism · 2019Review
- Functioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report.Journal of neurological surgery. Part B, Skull base · 2019Article
- Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.Reviews in endocrine & metabolic disorders · 2018Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Xanthomatous lesions of the sellar region have traditionally been divided into two separate categories, xanthomatous hypophysitis (XH) and xanthogranuloma (XG) of the sellar region. The seminal article on XH, a condition typified by foamy histiocytes and lymphoplasmacytic infiltrates in the pituitary gland/sellar region, but usually little or no hemosiderin pigment, detailed three patients. However, most reports since that time have been single cases, making understanding of the entity difficult. In contrast, the seminal report on XG, characterized by sellar region cholesterol clefts, lymphoplasmacytic infiltrates, marked hemosiderin deposits, fibrosis, multinucleated giant cells around cholesterol clefts, eosinophilic granular necrotic debris, and accumulation of macrophages, included 37 patients, allowing more insights into etiology. Few examples could be linked to adamantinomatous craniopharyngioma, and although ciliated epithelium similar to that of Rathke cleft cyst (RCC) was identified up to 35% of the 37 cases, it could not be proven that XG was related to hemorrhage into RCC. Case reports since that time, however, occasionally linked XG to RCC when an etiology could be identified at all, and a few recognized that a spectrum exists in xanthomatous lesions of the sella. They review literature, adding 23 cases from our own experience, to confirm that overlap occurs between XH and XG, and that the majority-but not all-can be linked to RCC leakage/rupture/hemorrhage. It was suggested that progressive accumulation of hemosiderin pigment in the lesion, possibly caused by the multiple episodes of bleeding, could account for the transition of at least some cases of XH to XG.
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Registered trials
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