ArticleJournal of magnetic resonance imaging : JMRI2017
Cardiac MR elastography for quantitative assessment of elevated myocardial stiffness in cardiac amyloidosis.
Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 94 citations in OpenAlex.
- QuantitativeEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Light-assisted 3D bioprinting of tough hydrogels in biomedical applications.Materials today. Bio · 2026Review
- Cardiovascular Magnetic Resonance Elastography: Current Evidence, Challenges, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2026Review
- Cardiac Shear Wave Elastography: Principles, Clinical Applications, and Practical Considerations for Interpretation.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Free-Breathing, 3D Cardiac Magnetic Resonance Elastography for Myocardial Stiffness Mapping.Magnetic resonance in medicine · 2026Article
- The Emerging Role of Mechanobiology in Connecting Metabolic and Cardiovascular Diseases: From Fundamentals to Future Therapies.Biomedicines · 2026Review
- Article
- Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration.Magnetic resonance in medicine · 2025Article
- Cardiac Magnetic Resonance Imaging in Heart Failure With Preserved Ejection Fraction.Circulation. Cardiovascular imaging · 2025Review
- Cardiac Magnetic Resonance Elastography: Why Multiplex Approaches Hold the Key to Clinical Translation.Journal of magnetic resonance imaging : JMRI · 2025Article
- Distinguishing shear and tensile myocardial wall stiffness using ex vivo anisotropic Magnetic Resonance Elastography.Acta biomaterialia · 2025Article
- Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis.JACC. Basic to translational science · 2025Article
- Supramolecular Conductive Hydrogels With Homogeneous Ionic and Electronic Transport.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Rheological Investigation of Polydimethylsiloxane with Glass Beads: A Model for Compression-Stiffening Effects in Soft Tissue Engineering.Materials (Basel, Switzerland) · 2025Article
- Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction.Cell reports · 2025Article
- Non-Invasive Hemodynamic Assessment of Heart Failure With Preserved Ejection Fraction.Korean circulation journal · 2025Review
- CMR to characterize myocardial structure and function in heart failure with preserved left ventricular ejection fraction.European heart journal. Cardiovascular Imaging · 2024Review
- 3D-Printable Gelatin Methacrylate-Xanthan Gum Hydrogel Bioink Enabling Human Induced Pluripotent Stem Cell Differentiation into Cardiomyocytes.Journal of functional biomaterials · 2024Article
- A Versatile MR Elastography Research Tool with a Modified Motion Signal-to-noise Ratio Approach.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography.Radiology. Cardiothoracic imaging · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate if cardiac magnetic resonance elastography (MRE) can measure increased stiffness in patients with cardiac amyloidosis. Myocardial tissue stiffness plays an important role in cardiac function. A noninvasive quantitative imaging technique capable of measuring myocardial stiffness could aid in disease diagnosis, therapy monitoring, and disease prognostic strategies. We recently developed a high-frequency cardiac MRE technique capable of making noninvasive stiffness measurements. MATERIALS AND
methodsIn all, 16 volunteers and 22 patients with cardiac amyloidosis were enrolled in this study after Institutional Review Board approval and obtaining formal written consent. All subjects were imaged head-first in the supine position in a 1.5T closed-bore MR imager. 3D MRE was performed using 5 mm isotropic resolution oblique short-axis slices and a vibration frequency of 140 Hz to obtain global quantitative in vivo left ventricular stiffness measurements. The median stiffness was compared between the two cohorts. An octahedral shear strain signal-to-noise ratio (OSS-SNR) threshold of 1.17 was used to exclude exams with insufficient motion amplitude.
resultsFive volunteers and six patients had to be excluded from the study because they fell below the 1.17 OSS-SNR threshold. The myocardial stiffness of cardiac amyloid patients (median: 11.4 kPa, min: 9.2, max: 15.7) was significantly higher (P = 0.0008) than normal controls (median: 8.2 kPa, min: 7.2, max: 11.8).
conclusionThis study demonstrates the feasibility of 3D high-frequency cardiac MRE as a contrast-agent-free diagnostic imaging technique for cardiac amyloidosis. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1361-1367.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.