ArticleJournal of clinical laboratory analysis2018
Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Identifying Diabetic Kidney Disease in Type 2 Diabetes Patients Using Explainable Machine Learning: A Case-Control Study.Journal of diabetes research · 2026Article
- Urinary Ferritin as an Early Indicator of Tubular Injury in Diabetic Kidney Disease: Insights from NHANES and Clinical Cohorts.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Urine biomarkers in type 2 diabetes mellitus with or without microvascular complications.Nutrition & diabetes · 2024Article
- Diagnostic value of α1-MG and URBP in early diabetic renal impairment.Frontiers in physiology · 2023Article
- Prediction of the Short-Term Risk of New-Onset Renal Dysfunction in Patients with Type 2 Diabetes: A Longitudinal Observational Study.Journal of immunology research · 2022Observational
- Article
- Combining glomerular basement membrane and tubular basement membrane assessment improves the prediction of diabetic end-stage renal disease.Journal of diabetes · 2021Article
- Current updates on protein as biomarkers for diabetic kidney disease: a systematic review.Therapeutic advances in endocrinology and metabolism · 2021Review
- Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy.The Journal of international medical research · 2020Article
- Article
- A study on the biological reference interval of urinary alpha 1-microglobulin in a group of Chinese people.Journal of clinical laboratory analysis · 2018Article
- Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients.Journal of clinical laboratory analysis · 2018Article
- Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients.Mediators of inflammation · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the associations of urinary markers (eg albumin), glomerular (eg transferrin [TRF], immunoglobulin G [IgG]), and tubular (eg α1-microglobulin [α1-MG], β2-microglobulin [β2-MG]) markers with the development of diabetic kidney disease (DKD) in type 2 diabetes patients, as assessed by estimated glomerular filtration rate (eGFR) and albuminuria. MATERIAL AND
methodsA total of 252 type 2 diabetes patients and 50 nondiabetic controls from Tianjin, China, were selected. Diabetic patients were divided into three groups according to eGFR levels, including groups A, B, and C with eGFR ≥90 (n=94), 60-89 (n=94), and 30-59 (n=64) mL/min/1.73 m
resultsUrinary levels of IgG, TRF, and β2-MG were significantly elevated in diabetic patients with normal eGFR compared with nondiabetic control subjects. Urinary levels of all markers increased per eGFR stratum. All kidney damage markers were significantly associated with eGFR in univariate analysis (standard β between -0.35 and -0.28; all P<.001). After adjusting for known confounders, only the tubular markers α1-MG (standard β=-0.25; P=.013) and β2-MG (standard β=-0.18; P=.039) retained significant associations with eGFR. All kidney damage markers were significantly associated with albuminuria, independent of age, duration of diabetes, and eGFR (standard β between 0.45 and 0.86; all P<.001).
conclusionOnly the tubular markers α
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