ArticleParasitology research2017
In-silico screening, identification and validation of a novel vaccine candidate in the fight against Plasmodium falciparum.
Article in Parasitology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice.NPJ vaccines · 2025Article
- Article
- Structure-Based Immunogenicity Prediction of Uricase from Fungal (Aspergillus flavus), Bacterial (Bacillus subtillis) and Mammalian Sources Using Immunoinformatic Approach.The protein journal · 2020Article
- Molecular epidemiology, pathogenicity, and structural analysis of haemoglobin variants in the Yunnan province population of Southwestern China.Scientific reports · 2019Article
- Plasmodium vivax Pv12 B-cell epitopes and HLA-DRβ1*-dependent T-cell epitopes in vitro antigenicity.PloS one · 2018Article
- TheFrontiers in cellular and infection microbiology · 2018Article
- Structural and inhibition analysis of novel sulfur-rich 2-mercaptobenzothiazole and 1,2,3-triazole ligands against Mycobacterium tuberculosis DprE1 enzyme.Journal of molecular modeling · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the enormous genetic plasticity of malaria parasite, the challenges of developing a potential malaria vaccine candidate with highest efficacy still remain. This study has incorporated a bioinformatics-based screening approach to explore potential vaccine candidates in Plasmodium falciparum proteome. A systematic strategy was defined to screen proteins from the Malaria Parasite Metabolic Pathways (MPMP) database, on the basis of surface exposure, non-homology with host proteome, orthology with related Plasmodium species, and MHC class I and II binding promiscuity. The approach reported PF3D7_1428200, a putative metabolite transporter protein, as a novel vaccine candidate. RaptorX server was used to generate the 3D model of the protein and was validated by PROCHECK. Furthermore, the predicted B cell and T cell epitopes with the highest score were subjected to energy minimization by molecular dynamics simulation to examine their stability within a solvent system. Results from this study could facilitate selection of proteins for entry into vaccine production pipeline in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.