Evidence map›Paper›PMID 28236167›Full record

ArticleBrain imaging and behavior2018

Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study.

Pablo D Perez, Gabrielle Hall, Jasenka Zubcevic, Marcelo Febo

Open access · greenAbstract readComparative Study
In one paragraph

Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pablo D PerezDepartment of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Gabrielle HallDepartment of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Jasenka ZubcevicDepartment of Physiological Sciences, College of Medicine, University of Florida, Gainesville, FL, USA.
Marcelo FeboDepartment of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. febo@ufl.edu.
University of Florida · US

Funding

Brain Imaging of Cocaine and Maternal RewardR01DA019946 · NIDA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2007 to 2011
$1.6M
Imaging In Vivo Neural Mechanisms of Synthetic Cathinones (Bath Salts)R21DA038009 · NIDA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2016
$411k
NIDA NIH HHS DA038009NIDA NIH HHS R01 DA019946NIDA NIH HHS R21 DA038009
6 · The paper itself

Abstract

Manganese enhanced magnetic resonance imaging (MEMRI) has been previously used to determine the effect of acute cocaine on calcium-dependent synaptic activity in male rats. However, there have been no MEMRI studies examining sex differences in the functional neural circuits affected by repeated cocaine. In the present study, we used MEMRI to investigate the effects of repeated cocaine on brain activation in female and male rats. Adult female and male rats were scanned at 4.7 Tesla three days after final treatment with saline, a single cocaine injection (15 mg kg

Indexed as

Sex CharacteristicsAnimalsChloridesCocaineContrast MediaDopamine Uptake InhibitorsDrug Administration ScheduleFemaleMagnetic Resonance ImagingMaleManganese CompoundsMemoryMesencephalonMotor ActivityRats, Long-EvansStereotyped BehaviorChloridesCocaineContrast MediaDopamine Uptake Inhibitorsmanganese chlorideManganese CompoundsAddictionCocaineManganeseMEMRISex differencesSynaptic activity

Identifiers

PMID28236167
PMCPMC6397741
OpenAlexW2589155296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.