ReviewPflugers Archiv : European journal of physiology2017
Resident macrophages in the healthy and inflamed intestinal muscularis externa.
Review in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- New insights into muscularis macrophages in the gut: from their origin to therapeutic targeting.Immunologic research · 2023Review
- Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease.Cellular and molecular gastroenterology and hepatology · 2022Review
- Sympathetic Denervation Alters the Inflammatory Response of Resident Muscularis Macrophages upon Surgical Trauma and Ameliorates Postoperative Ileus in Mice.International journal of molecular sciences · 2021Article
- Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis.Clinical and translational gastroenterology · 2021Observational
- Class A1 scavenger receptors mediated macrophages in impaired intestinal barrier of inflammatory bowel disease.Annals of translational medicine · 2020Article
- Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease.Frontiers in immunology · 2020Review
- Postoperative Ileus and Postoperative Gastrointestinal Tract Dysfunction: Pathogenic Mechanisms and Novel Treatment Strategies Beyond Colorectal Enhanced Recovery After Surgery Protocols.Frontiers in pharmacology · 2020Review
- A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative IleusFrontiers in immunology · 2020Article
- Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation.Histochemistry and cell biology · 2019Article
- Functional macrophages and gastrointestinal disorders.World journal of gastroenterology · 2018Review
- The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages reside in a dense cellular network in the intestinal muscularis externa, and there is emerging evidence that the functionality of these cells determines the local microenvironment. Inflammatory responses during intestinal diseases change the homeostatic functionality of these cells causing inflammation and intestinal dysmotility. Such disturbances are not only induced by a change in the cellular composition in the intestinal muscularis but also by an altered crosstalk with the peripheral and central nervous system. In this review, we summarize the role of muscularis macrophages in the intestine in homeostasis and inflammation. We compare the functionality, the phenotype, and the origin of muscularis macrophages to their neighboring counterparts within the different layers of the intestine. We outline the cellular crosstalk with the enteric and the peripheral nervous system and summarize the current therapeutic approaches to modulate the functionality of these phagocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.