Evidence map›Paper›PMID 28236062›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2017

Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy.

H Nazif, R Shatla, R Elsayed, E Tawfik, N Osman, S Korra, A Ibrahim

Abstract read
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  2. Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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  6. Potential applications for rhIGF-I: Bone disease and IGFI.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

H NazifDepartment of Childhood Medical Studies, Institute of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt.
R ShatlaDepartment of Pediatrics, Pediatric Neurology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
R ElsayedDeparment of Pediatrics, Pediatric Neurology Unit, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. shewaka1971@yahoo.com.
E TawfikDepartment of Physical Medicine, Rheumatology and Rehabilitation Faculty of Medicine, Ain Shams University, Cairo, Egypt.
N OsmanDepartment of Radio Diagnoses, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
S KorraDepartment of Molecular Biology, National Center for Radiation Research and Technology, Cairo, Egypt.
A IbrahimDepartment of Childhood Medical Studies, Institute of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt.
Ain Shams University · EGMansoura University · EGNational Water Research Center · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with cerebral palsy (CP) have significant decrease linear growth rate and low bone mineral density (BMD).

aimsThis study is to evaluate BMD in children with CP and its relation to the levels of insulin-like growth factor-1 (IGF-1). SUBJECTS AND

methodsThis cross-sectional study was carried out on 58 children suffering from spastic CP with the age range 4-12 years compared to 19 controls. All assessed by dual energy x-ray absorptiometry (DXA) to measure BMD, serum level of IGF-1, and serum vitamin D. The patients were classified according to their GMFCS.

resultsFractures were reported in seven (12.1%) of cases. Our study demonstrated that, IGF-1 level and BMD decrease in correlation with the severity of CP. IGF-1correlates positively with serum vitamin D, BMI, and BMD. CP children with severe GMFCS level or who use anticonvulsive drugs are at a high risk for low BMD and low levels of IGF-1.

conclusionBoth BMD and IGF-1 were significantly in low children with spastic CP; IGF-1 negatively correlates with the severity of osteopenia in children with spastic. Children with CP who are not independently ambulant or with severe GMFCS level or who use anticonvulsive drugs are at a high risk for developing low BMD.

Indexed as

Absorptiometry, PhotonAnticonvulsantsBone DensityBone Diseases, MetabolicCerebral PalsyChildCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayEpilepsyFemaleHumansInsulin-Like Growth Factor ILinear ModelsMaleSeverity of Illness IndexVitamin DAnticonvulsantsInsulin-Like Growth Factor IVitamin DBone mineral densityIGF-1Spastic CPVitamin D

Identifiers

PMID28236062
OpenAlexW2590147629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.