Evidence map›Paper›PMID 28236059›Full record

ArticleVirchows Archiv : an international journal of pathology2017

EWSR1 rearrangement is a frequent event in papillary thyroid carcinoma and in carcinoma of the thyroid with Ewing family tumor elements (CEFTE).

G Oliveira, A Polónia, J M Cameselle-Teijeiro, D Leitão, S Sapia, M Sobrinho-Simões, C Eloy

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Spindle lesions in the thyroid: a cytological and histological review.Virchows Archiv : an international journal of pathology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

G OliveiraIpatimup Diagnostics, Institute of Molecular Pathology and Immunology of Porto University, R. Júlio Amaral de Carvalho, 45, Ipatimup, 4200-135, Porto, Portugal.
A PolóniaIpatimup Diagnostics, Institute of Molecular Pathology and Immunology of Porto University, R. Júlio Amaral de Carvalho, 45, Ipatimup, 4200-135, Porto, Portugal.
J M Cameselle-TeijeiroDepartment of Anatomic Pathology, Clinical University Hospital, Servicio Gallego de Salud (SERGAS), University of Santiago de Compostela, Santiago de Compostela, Spain.
D LeitãoIpatimup Diagnostics, Institute of Molecular Pathology and Immunology of Porto University, R. Júlio Amaral de Carvalho, 45, Ipatimup, 4200-135, Porto, Portugal.
S SapiaPathology Department, Vinalopó Hospital, Elche, Spain.
M Sobrinho-SimõesIpatimup Diagnostics, Institute of Molecular Pathology and Immunology of Porto University, R. Júlio Amaral de Carvalho, 45, Ipatimup, 4200-135, Porto, Portugal.
C EloyIpatimup Diagnostics, Institute of Molecular Pathology and Immunology of Porto University, R. Júlio Amaral de Carvalho, 45, Ipatimup, 4200-135, Porto, Portugal. celoy@ipatimup.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinomas of the thyroid with Ewing family tumor element (CEFTEs) are small-cell thyroid tumors with epithelial differentiation that disclose p63 expression and EWSR1-FLI1 rearrangement, carry a favorable prognosis and may co-exist with papillary thyroid carcinoma (PTC) foci. Two histogenetic hypotheses have been advanced regarding the origin of CEFTEs: arising in PTCs or in solid cell nests (SCN). A total of 3 CEFTEs, 54 PTCs, and 10 SCNs were reviewed, and fluorescence in situ hybridization (FISH) technique was performed in all cases to search for the presence of EWSR1 rearrangements. The three CEFTEs disclosed the EWSR1-FLI1 rearrangement both in the small cell and in the PTC component. Out of the 54 PTC cases, 28 (51.9%) were positive, 20 (37.0%) were negative, and 6 (11.1%) were inconclusive for EWSR1 rearrangement; in two of the positive PTC cases, the EWSR1-FLI1 rearrangement was detected. Classic PTC disclosed more often the EWSR1 rearrangement than other PTC variants (p = 0.031). PTCs with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement (p = 0.001). Out of the 10 SCNs, 7 (70.0%) were negative and 3 (30.0%) were inconclusive for the EWSR1 rearrangement. Monosomic nuclei were more frequent (mean of 44.3%) in SCNs than in PTCs (p < 0.001). The presence of the EWSR1-FLI1 rearrangement in PTC component of all studied CEFTEs and the existence of the EWSR1 rearrangement in some PTCs favor the origin of CEFTE from PTC. The high frequency of EWSR1 rearrangements in PTC may represent a new diagnostic marker of these tumors.

Indexed as

AdolescentAdultAgedCarcinomaCarcinoma, PapillaryChildFemaleHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMiddle AgedOncogene Proteins, FusionReal-Time Polymerase Chain ReactionThyroid Cancer, PapillaryThyroid NeoplasmsEWSR1-FLI1 fusion protein, humanOncogene Proteins, FusionEwing sarcomaEWSR1-FLI1EWSR1 rearrangementPapillary thyroid carcinomaSmall cell carcinoma

Identifiers

PMID28236059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.