Evidence map›Paper›PMID 28236055›Full record

ArticleDiabetologia2017

Metabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options.

Domenico Tricò, Raimund I Herzog

Abstract readLetter
In one paragraph

Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Domenico TricòDepartment of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208020, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0002-7633-1346
Raimund I HerzogDepartment of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208020, New Haven, CT, 06520, USA. raimund.herzog@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Regulation of Brain Glucose Metabolism in Type 1 DiabetesR01DK101984 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO · 2014 to 2023
$3.8M
Reversing brain metabolic adaptations to recurrent hypoglycemia in older adults with type 1 diabetes using a Predictive Low Glucose Management (PLGM) systemDP3DK112227 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO, WEINZIMER, STUART ALAN · 2016 to 2016
$1.9M
Human Brain Ketone Metabolism in Type 1 Diabetes and Hypoglycemia.R03DK100709 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO · 2014 to 2015
$164k
NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIDDK NIH HHS DP3 DK112227NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK101984NIDDK NIH HHS R03 DK100709
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood-Brain BarrierCase-Control StudiesDiabetes Mellitus, Type 1EpilepsyFemaleHumansHypoglycemiaKetonesMaleModels, NeurologicalNeuronsRecurrenceRetrospective StudiesTreatment OutcomeKetonesBrain metabolismEpilepsyHypoglycaemiaLactateType 1 diabetesβ-hydroxybutyrate

Identifiers

PMID28236055
PMCPMC5395303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.