Evidence map›Paper›PMID 28235873›Full record

ArticleApplied and environmental microbiology2017

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

Thomas S Peat, Sahil Balotra, Matthew Wilding, Carol J Hartley, Janet Newman, Colin Scott

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Thomas S PeatCSIRO Biomedical Manufacturing, Parkville, Victoria, Australia.
Sahil BalotraResearch School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Matthew WildingCSIRO Land and Water, Black Mountain, Canberra, Australian Capital Territory, Australia.
Carol J HartleyCSIRO Land and Water, Black Mountain, Canberra, Australian Capital Territory, Australia.
Janet NewmanCSIRO Biomedical Manufacturing, Parkville, Victoria, Australia.
Colin ScottCSIRO Land and Water, Black Mountain, Canberra, Australian Capital Territory, Australia Colin.scott@csiro.au.
CSIRO Land and Water · AUCSIRO Manufacturing · AUACT GovernmentAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Toblerone fold was discovered recently when the first structure of the cyclic amide hydrolase, AtzD (a cyanuric acid hydrolase), was elucidated. We surveyed the cyclic amide hydrolase family, finding a strong correlation between phylogenetic distribution and specificity for either cyanuric acid or barbituric acid. One of six classes (IV) could not be tested due to a lack of expression of the proteins from it, and another class (V) had neither cyanuric acid nor barbituric acid hydrolase activity. High-resolution X-ray structures were obtained for a class VI barbituric acid hydrolase (1.7 Å) from a

Indexed as

AmidohydrolasesCatalytic DomainCluster AnalysisComputational BiologyCrystallography, X-RayFrankiaMetalsModels, MolecularPhylogenyProtein ConformationRhodococcusSequence HomologyAmidohydrolasesMetalsatrazineevolutionhydrolasephylogenetic analysisstructure-activity relationshipstriazine

Identifiers

PMID28235873
PMCPMC5394311
OpenAlexW2591185224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.