Trial reportAddictive behaviors2017
Timing of nicotine lozenge administration to minimize trigger induced craving and withdrawal symptoms.
Trial report in Addictive behaviors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01522963 (Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms
Who cites it
10 citing papers in PubMed.
- Feasibility and Acceptability of a Smoking Cessation Program for Individuals Released From an Urban, Pretrial Jail: A Pilot Randomized Clinical Trial.JAMA network open · 2021Trial
- Effect of nicotine lozenge use prior to smoking cue presentation on craving and withdrawal symptom severity.Drug and alcohol dependence · 2020Trial
- Relative importance of temporal and location features in predicting smoking events.NPJ digital medicine · 2025Article
- Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy.Psychopharmacology · 2022Article
- Examining the effect of exercise on the relationship between affect and cravings among smokers engaged in cessation treatment.Addictive behaviors · 2022Article
- Perceptions, behaviours and attitudes towards smoking held by the male partners of Chinese pregnant women: a qualitative study.BMC public health · 2021Article
- Using consumer-wearable technology for remote assessment of physiological response to stress in the naturalistic environment.PloS one · 2020Article
- Predicting Smoking Events with a Time-Varying Semi-Parametric Hawkes Process Model.Proceedings of machine learning research · 2018Article
- Effects of smoking and paroxetine on stress-induced craving and withdrawal symptoms.Journal of substance use · 2018Article
- Sex differences in physiological response to the combination of stress and smoking.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionSmokers are often advised to use nicotine lozenge when craving or withdrawal symptoms occur. This may be too late to prevent lapses. This study assessed if nicotine lozenge use prior to a common smoking trigger can minimize trigger induced increases in craving and withdrawal symptoms.
methodsEighty-four smokers completed two laboratory sessions in random order. At one session, nicotine lozenge was given immediately after a stressor (to approximate current recommended use - i.e., after craving and withdrawal symptoms occur); at the other session subjects were randomized to receive nicotine lozenge at time points ranging from immediately to 30min prior to the stressor. Withdrawal symptoms and urge to smoke were measured using the Minnesota Nicotine Withdrawal Scale and the Questionnaire of Smoking Urges (QSU).
resultsRelative to receiving lozenge after the stressor, a smaller increase in pre-stressor to post-stressor withdrawal symptom scores occurred when lozenge was used immediately (p=0.03) and 10min prior (p=0.044) to the stressor. Results were similar for factors 1 and 2 of the QSU when lozenge was used immediately prior to the stressor (p<0.03) and for factor 1 of the QSU when lozenge was used 10min prior to the stressor (p=0.028). Absolute levels of post-stressor withdrawal symptom and urge to smoke severity were lower when lozenge was given prior to versus after a stressor.
conclusionsAdministering the nicotine lozenge prior to a smoking trigger can decrease trigger induced craving and withdrawal symptoms. Future studies are needed to determine if such use would increase cessation rates. Clinicaltrials.gov # NCT01522963.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.