Evidence map›Paper›PMID 28235591›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2017

Folate-mediated chemotherapy and diagnostics: An updated review and outlook.

Leyuan Xu, Qianming Bai, Xin Zhang, Hu Yang

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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  17. The Employment of GeneraNutrients · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leyuan XuDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States; Department of Internal Medicine, Yale University, New Haven, CT 06520, United States.
Qianming BaiDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xin ZhangDepartment of Pathology, Fudan University Zhongshan Hospital, Shanghai 200032, China.
Hu YangDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, United States; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States. Electronic address: hyang2@vcu.edu.

Funding

Hybrid Nanoparticles for GlaucomaR01EY024072 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KOMPELLA, UDAY B, YANG, HU · 2014 to 2016
$1.3M
NEI NIH HHS R01 EY024072
6 · The paper itself

Abstract

Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.

Indexed as

AnimalsAntineoplastic AgentsDrug Delivery SystemsDrug LiberationFolate Receptors, GPI-AnchoredFolic AcidHumansMolecular ProbesMolecular Targeted TherapyNanoparticlesNeoplasmsTheranostic NanomedicineAntineoplastic AgentsFolate Receptors, GPI-AnchoredFolic AcidMolecular ProbesDiagnosisFolate receptorFolic acidNanomedicineTargeted delivery

Identifiers

PMID28235591
PMCPMC5479736

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.