Evidence map›Paper›PMID 28235545›Full record

ReviewNeuroscience and biobehavioral reviews2017

Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease.

Mohamad El Haj, Jean Roche, Renaud Jardri, Dimitrios Kapogiannis, Karim Gallouj, Pascal Antoine

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

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  9. Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Mohamad El HajUniv. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France. Electronic address: mohamad.elhaj@univ-lille3.fr.
Jean RocheCHU de Lille, Unité de Psychogériatrie, Pôle de gérontologie, 59037 Lille, France.
Renaud JardriUniv. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France.
Dimitrios KapogiannisLaboratory of Neurosciences, National Institute on Aging, Baltimore, MD, USA.
Karim GalloujDepartment of Geriatrics, Tourcoing Hospital, France.
Pascal AntoineUniv. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France.
Centre Hospitalier de Tourcoing · FRCentre Hospitalier Universitaire de Lille · FRCentre National de la Recherche Scientifique · FRNational Institute on Aging · USSciences Cognitives et Sciences Affectives · FRUniversité de Lille · FR

Funding

Studies in Dementia and Neurodegenerative DiseasesZIAAG000975 · NIA · NATIONAL INSTITUTE ON AGING · PI KAPOGIANNIS, DIMITRIOS · 2009 to 2025
$31.5M
Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA AG000975
6 · The paper itself

Abstract

Due to their prevalence, hallucinations are considered as one of the most frequent psychotic symptoms in Alzheimer's disease (AD). These psychotic manifestations reduce patients' well-being, increase the burden of caregivers, contribute to early institutionalization, and are related with the course of cognitive decline in AD. Considering their consequences, we provide a comprehensive account of the current state of knowledge about the prevalence and characteristics of hallucinations in AD. We propose a comprehensive and testable theoretical model about hallucinations in AD: the ALZHA (ALZheimer and HAllucinations) model. In this model, neurological, genetic, cognitive, affective, and iatrogenic factors associated with hallucinations in AD are highlighted. According to the ALZHA model, hallucinations in AD first involve trait markers (i.e., cognitive deficits, neurological deficits, genetic predisposition and/or sensory deficits) to which state markers that may trigger these experiences are added (e.g., psychological distress and/or iatrogenic factors). Finally, we provide recommendations for assessment and management of these psychotic manifestations in AD, with the aim to benefit patients, caregivers, and health professionals.

Indexed as

Alzheimer DiseaseBrainCognitive DysfunctionDisease ManagementHallucinationsHumansNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersAlzheimer’s diseaseClinical managementHallucinations

Identifiers

PMID28235545
PMCPMC5565710
OpenAlexW2589712282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.