ArticleJournal of translational medicine2017
A rabbit model for experimental alveolar cleft grafting.
Article in Journal of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Current Animal Models of Cleft Lip and/or Palate: A Narrative Review.Biomedicines · 2026Review
- A novel pilot animal model for bone augmentation using osseous shell technique for preclinical in vivo studies.Clinical and experimental dental research · 2022Article
- Development of root resorption during orthodontic tooth movement after cleft repair using different grafting materials in rats.Clinical oral investigations · 2022Article
- The effect of biphasic calcium phosphate and demineralized bone matrix on tooth eruption in mongrel dogs.Archives of craniofacial surgery · 2021Article
- Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats.Scientific reports · 2021Article
- A novel surgical model for the preclinical assessment of the osseointegration of dental implants: a surgical protocol and pilot study results.Journal of translational medicine · 2021Article
- Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model.Tissue engineering. Part A · 2021Article
- Biomaterials for Cleft Lip and Palate Regeneration.International journal of molecular sciences · 2019Review
- Bone regeneration using composite non-demineralized xenogenic dentin with beta-tricalcium phosphate in experimental alveolar cleft repair in a rabbit model.Journal of translational medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of the present study was to develop an animal model for creating alveolar cleft defects with properly simulated clinical defect environment for tissue-engineered bone-substitute materials testing without compromising the health of the animal. Cleft creation surgery was aimed at creating a complete alveolar cleft with a wide bone defect with an epithelial lining (oral mucosa) overlying the cleft defect.
methodsA postmortem skull of a New Zealand White (NZW) rabbit skull (Oryctolagus cuniculus) underwent an osteological and imaging survey. A pilot postmortem surgery was conducted to confirm the feasability of a surgical procedure and the defect was also radiologically confirmed and illustrated with micro-computed tomography. Then, a surgical in vivo model was tested and evaluated in 16 (n = 16) 8-week-old NZW rabbits to create in vivo alveolar cleft creation surgery.
resultsClinical examination and imaging analysis 8 weeks after cleft creation surgery revealed the establishment of a wide skeletal defect extending to the nasal mucosa simulating alveolar clefts in all of the rabbits.
conclusionsOur surgical technique was successful in creating a sizable and predictable model for bone grafting material testing. The model allows for simulating the cleft site environment and can be used to evaluate various bone grafting materials in regard to efficacy of osteogenesis and healing potential without compromising the health of the animal.
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