ArticlePloS one2017
Hyperthermia influences fate determination of neural stem cells with lncRNAs alterations in the early differentiation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.Science advances · 2021Article
- Hyperthermia Disturbs and Delays Spontaneous Differentiation of Human Embryoid Bodies.Biomedicines · 2020Article
- The functions of long non-coding RNAs in neural stem cell proliferation and differentiation.Cell & bioscience · 2020Review
- Article
- Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemperature is an important parameter in the microenvironment of neural stem cells (NSCs); however, little is known about the precise effects of hyperthermia on fate determination in NSCs or the role of long non-coding (lnc)RNAs in this process. This was addressed in the present study using NSCs cultured at two different temperatures.
methodsNSCs were divided into 37NSC and 40NSC groups that were cultured at 37°C or 40°C, respectively, for 72 h. Neuronal or glial cell differentiation was evaluated by flow cytometry and western blotting. LncRNA expression was detected by quantitative real-time PCR.
resultsThe numbers of cells positive for the neuronal marker Tuj-1 and the glial cell marker glial fibrillary acidic protein were higher in the 40NSC than in the 37NSC group. The two groups also showed distinct lncRNA expression profiles.
conclusionHyperthermia promotes neuronal and glial differentiation in NSCs, which involves specific lncRNAs.
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