ReviewShock (Augusta, Ga.)2017
Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis?
Review in Shock (Augusta, Ga.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review.Microcirculation (New York, N.Y. : 1994) · 2020Pooled it
- Clinical Significance of Rotational Thromboelastometry (ROTEM) for Detection of Early Coagulopathy in Trauma Patients: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Development and Validation of a Nomogram for Predicting Sepsis-Induced Coagulopathy in Septic Patients: Mixed Retrospective and Prospective Cohort Study.Thrombosis and haemostasis · 2025Article
- Early prediction of sepsis-induced coagulopathy in the ICU using interpretable machine learning: a multi-center retrospective cohort study.Frontiers in medicine · 2025Article
- Circulating NETs enable early identification of thrombotic risk in sepsis at emergency care onset.Frontiers in immunology · 2025Article
- The prevalence, risk factors, and outcomes of acute pulmonary embolism complicating sepsis and septic shock: a national inpatient sample analysis.Scientific reports · 2024Article
- Sepsis-Associated Coagulopathy Predicts Hospital Mortality in Critically Ill Patients With Postoperative Sepsis.Frontiers in medicine · 2022Article
- Acquired haemophilia in patients with malignant disease: A case report.World journal of clinical cases · 2021Article
- Burn-Induced Coagulopathies: a Comprehensive Review.Shock (Augusta, Ga.) · 2020Review
- Comparative Analysis of Three Machine-Learning Techniques and Conventional Techniques for Predicting Sepsis-Induced Coagulopathy Progression.Journal of clinical medicine · 2020Article
- Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.Transfusion · 2020Article
- A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients.The journal of trauma and acute care surgery · 2020Observational
- Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation-A Proof-of-Concept Study.Journal of clinical medicine · 2020Article
- Enigmatic role of coagulopathy among sepsis survivors: a review of coagulation abnormalities and their possible link to chronic critical illness.Trauma surgery & acute care open · 2020Review
- A Machine Learning-Based Prediction of Hospital Mortality in Patients With Postoperative Sepsis.Frontiers in medicine · 2020Article
- An evaluation of clinical inflammatory and coagulation markers in patients with sepsis: a pilot study.Acute medicine & surgery · 2019Article
- An Assessment of the Academic Impact of Shock Society Members.Shock (Augusta, Ga.) · 2018Article
- Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Coagulopathy is a common and vexing clinical problem in critically ill patients. Recently, major advances focused on the treatment of coagulopathy in trauma and sepsis have emerged. However, the targeting of coagulopathy with blood product transfusion and drugs directed at attenuating the physiologic response to these conditions has major potential risk to the patient. Therefore, the identification of coagulopathy as a clinical target is an area of uncertainty and controversy. To analyze the state of the science regarding coagulopathy in critical illness, a symposium addressing the problem was organized at the 39th annual meeting of the Shock Society in the summer of 2016. This manuscript synthesizes the viewpoints of the four expert panelists at the debate and presents an overview of the potential positive and negative consequences of targeting coagulopathy in trauma and sepsis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.