ArticleJournal of psychiatry & neuroscience : JPN2017
Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection.Frontiers in immunology · 2024Article
- Article
- The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model.Cells · 2022Review
- Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1Molecular autism · 2022Article
- LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.Journal of neurodevelopmental disorders · 2022Article
- Brain metastases: It takes two factors for a primary cancer to metastasize to brain.Frontiers in oncology · 2022Article
- New VOUS inMaedica · 2021Article
- Survival of a male patient harboring CASK Arg27Ter mutation to adolescence.Molecular genetics & genomic medicine · 2020Article
- A de novo frameshift pathogenic variant in TBR1 identified in autism without intellectual disability.Human genomics · 2020Article
- Haploinsufficiency of X-linked intellectual disability gene CASK induces post-transcriptional changes in synaptic and cellular metabolic pathways.Experimental neurology · 2020Article
- Anterior Commissure Regulates Neuronal Activity of Amygdalae and Influences Locomotor Activity, Social Interaction and Fear Memory in Mice.Frontiers in molecular neuroscience · 2020Article
- Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction.Frontiers in molecular neuroscience · 2019Article
- Article
- Two microcephaly-associated novel missense mutations in CASK specifically disrupt the CASK-neurexin interaction.Human genetics · 2018Article
- CA1NPJ aging and mechanisms of disease · 2018Article
- Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis.Asian journal of andrologyReview
- Genomic variants and inferred biological processes in multiplex families with Tourette syndrome.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman genetic studies have indicated that mutations in calcium/calmodulin-dependent serine protein kinase (
methodsBecause
resultsThe CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal. LIMITATIONS: The functions of other CASK protein interactions cannot be addressed using CASK T740A mice.
conclusionDisruption of the CASK and TBR1 interaction impairs extinction, suggesting the involvement of CASK in cognitive flexibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.