ArticleeLife2017
A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity.
Abstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.bioRxiv : the preprint server for biology · 2026Article
- Flexible Coupling of Synaptic and Intrinsic Plasticity in a Cerebellar Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Loss of dystrophin reduces CB1 receptor expression and endocannabinoid-dependent synaptic plasticity in the cerebellar cortex.bioRxiv : the preprint server for biology · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- Article
- Restoring cerebellar-dependent learning.eLife · 2024Article
- Article
- Enhancement of Motor Learning and Corticospinal Excitability: The Role of Electroacupuncture and Motor Training in Healthy Volunteers.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.bioRxiv : the preprint server for biology · 2024Article
- Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes.iScience · 2024Article
- Energy-aware bio-inspired spiking reinforcement learning system architecture for real-time autonomous edge applications.Frontiers in neuroscience · 2024Article
- Increased paired stimuli enhance corticospinal-motoneuronal plasticity in humans with spinal cord injury.Journal of neurophysiology · 2023Article
- Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity.Molecular brain · 2021Article
- Reexposure to a sensorimotor perturbation produces opposite effects on explicit and implicit learning processes.PLoS biology · 2021Article
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Regulation and Interaction of Multiple Types of Synaptic Plasticity in a Purkinje Neuron and Their Contribution to Motor Learning.Cerebellum (London, England) · 2018Review
- Inhibition gates supralinear CaeLife · 2018Article
- Computational Principles of Supervised Learning in the Cerebellum.Annual review of neuroscience · 2018Review
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Td Barbara Nguyen-VuDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.ORCID 0000-0002-4708-1982
Grace Q ZhaoDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.
Subhaneil LahiriDepartment of Applied Physics, Stanford University, Stanford, United States.ORCID 0000-0003-2028-6635
Rhea R KimpoDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.
Hanmi LeeDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.
Surya GanguliDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.
Carla J ShatzDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.
Jennifer L RaymondDepartment of Neurobiology, Stanford School of Medicine, Stanford, United States.ORCID 0000-0002-8145-747X
Funding
FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONSR01EY002858 · NEI · STANFORD UNIVERSITY · PI SHATZ, CARLA J · 1985 to 2020
$9.9MVESTIBULAR AND VISUAL CONTROL OF EYE MOVEMENTR01DC004154 · NIDCD · STANFORD UNIVERSITY · PI GOLDMAN, MARK S, RAYMOND, JENNIFER L · 1999 to 2025
$9.6MSynapse Remodeling and Neuronal MHC Class IR01MH071666 · NIMH · STANFORD UNIVERSITY · PI SHATZ, CARLA J · 2004 to 2019
$7.6MInstructive Signals for Motor LearningR01NS072406 · NINDS · STANFORD UNIVERSITY · PI Jennifer L Raymond · 2010 to 2026
$7.6MVECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2011 to 2019
$6.3MStanford OHNS Core CenterP30DC010363 · NIDCD · STANFORD UNIVERSITY · PI HELLER, STEFAN · 2009 to 2016
$3.0MCircuit Analysis by Rapid Silencing of Specific Interneuron Populations In VivoR21NS057488 · NINDS · STANFORD UNIVERSITY · PI RAYMOND, JENNIFER L · 2007 to 2009
$436kNeural mechanisms of cerebellum-dependent vestibulo-ocular reflex (VOR) learning.F31DC010547 · NIDCD · STANFORD UNIVERSITY · PI NGUYEN-VU, T.D.BARBARA BARBARA · 2009 to 2011
$71kThe role of cerebellar Golgi interneurons in the adaptive timing of movementsF32NS058060 · NINDS · STANFORD UNIVERSITY · PI ZHAO, GRACE Q · 2007 to 2007
$52kNEI NIH HHS R01 EY002858NIDCD NIH HHS F31 DC010547NIDCD NIH HHS P30 DC010363NIDCD NIH HHS R01 DC004154NIMH NIH HHS R01 MH071666NINDS NIH HHS F32 NS058060NINDS NIH HHS P30 NS069375NINDS NIH HHS R01 NS072406NINDS NIH HHS R21 NS057488
Abstract
Across many studies, animals with enhanced synaptic plasticity exhibit
Indexed as
LearningLearning DisabilitiesLong-Term PotentiationLong-Term Synaptic DepressionAnimalsMice, Inbred C57BLMice, KnockoutNeuronsOptogeneticscerebellumlearning & memorymouseneurosciencesynaptic plasticity
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.