ArticleJournal of psychiatry & neuroscience : JPN2017
COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume.
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Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptoms.International journal of molecular sciences · 2025Review
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child.BMC psychiatry · 2024Article
- Insights into the Involvement and Therapeutic Target Potential of the Dopamine System in the Posttraumatic Stress Disorder.Molecular neurobiology · 2023Review
- Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.International journal of molecular sciences · 2023Article
- Article
- Computational analysis of deleterious single nucleotide polymorphisms in catechol O-Methyltransferase conferring risk to post-traumatic stress disorder.Journal of psychiatric research · 2021Article
- Prenatal Maternal Stress From a Natural Disaster and Hippocampal Volumes: Gene-by-Environment Interactions in Young Adolescents From Project Ice Storm.Frontiers in behavioral neuroscience · 2021Article
- Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.International journal of molecular sciences · 2020Review
- Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.Translational psychiatry · 2020Article
- Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System.Frontiers in pharmacology · 2019Review
- BDNF genotype is associated with hippocampal volume in mild traumatic brain injury.Genes, brain, and behavior · 2018Article
- Resilience Against Traumatic Stress: Current Developments and Future Directions.Frontiers in psychiatry · 2018Review
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Authors and funding
15 authors at 1 institution in 1 country.
Jasmeet P HayesFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Mark W LogueFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Andrew ReaganFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
David SalatFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Erika J WolfFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Naomi SadehFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Jeffrey M SpielbergFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Emily SperbeckFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Scott M HayesFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Regina E McGlincheyFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
William P MilbergFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Mieke VerfaellieFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Annjanette StoneFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Steven A SchichmanFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
Mark W MillerFrom the National Center for PTSD, VA Boston Healthcare System, Boston, Mass. (Hayes, Reagan, Wolf, Sadeh, Miller); the Department of Psychiatry, Boston University School of Medicine, Boston, Mass. (Hayes, Wolf, Sadeh, Spielberg, Sperbeck, Hayes, Verfaellie, Miller); the Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Salat, Spielberg, Hayes); the Research Service, VA Boston Healthcare System, Boston, Mass. (Logue); the Biomedical Genetics, Boston University School of Medicine, Boston, Mass. (Logue); the Department of Biostatistics, Boston University School of Public Health, Boston, Mass. (Logue); the Memory Disorders Research Center, VA Boston Healthcare System, Boston, Mass. (Hayes, Verfaellie); the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard University, Boston, Mass. (Salat); the Harvard Medical School, Harvard University, Boston, Mass. (Salat); the Translational Research Center for TBI and Stress Disorders and Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Mass. (McGlinchey, Milberg); the Department of Psychiatry, Harvard Medical School, Boston, Mass. (McGlinchey, Milberg); the Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, USA (Stone, Schichman).
VA Boston Healthcare System · US
Funding
Neuroimaging Genetics of PTSDR21MH102834 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MILLER, MARK W · 2014 to 2015
$355kNeuroimaging Genetics of Mild TBII21RX001594 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HAYES, JASMEET PANNU · 2015 to 2016
–NIMH NIH HHS R21 MH102834RRD VA I21 RX001594
Abstract
backgroundMemory-based alterations are among the hallmark symptoms of posttraumatic stress disorder (PTSD) and may be associated with the integrity of the hippocampus. However, neuroimaging studies of hippocampal volume in individuals with PTSD have yielded inconsistent results, raising the possibility that various moderators, such as genetic factors, may influence this association. We examined whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism, which has previously been shown to be associated with hippocampal volume in healthy individuals, moderates the association between PTSD and hippocampal volume.
methodsRecent war veterans underwent structural MRI on a 3 T scanner. We extracted volumes of the right and left hippocampus using FreeSurfer and adjusted them for individual differences in intracranial volume. We assessed PTSD severity using the Clinician-Administered PTSD Scale. Hierarchical linear regression was used to model the genotype (Val158Met polymorphism) × PTSD severity interaction and its association with hippocampal volume.
resultsWe included 146 white, non-Hispanic recent war veterans (90% male, 53% with diagnosed PTSD) in our analyses. A significant genotype × PTSD symptom severity interaction emerged such that individuals with greater current PTSD symptom severity who were homozygous for the Val allele showed significant reductions in left hippocampal volume. LIMITATIONS: The direction of proposed effects is unknown, thus precluding definitive assessment of whether differences in hippocampal volume reflect a consequence of PTSD, a pre-existing characteristic, or both.
conclusionOur findings suggest that the COMT polymorphism moderates the association between PTSD and hippocampal volume. These results highlight the role that the dopaminergic system has in brain structure and suggest a possible mechanism for memory disturbance in individuals with PTSD.
Indexed as
Genetic Predisposition to DiseasePolymorphism, GeneticAdultCatechol O-MethyltransferaseCross-Sectional StudiesFemaleGenotyping TechniquesHippocampusHumansImaging, Three-DimensionalLinear ModelsMagnetic Resonance ImagingMaleOrgan SizePattern Recognition, AutomatedPsychiatric Status Rating ScalesCatechol O-MethyltransferaseCOMT protein, humancyromazineTriazines
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