Evidence map›Paper›PMID 28234208›Full record

Trial reportJournal of psychiatry & neuroscience : JPN2017

Psychobiological response to pain in female adolescents with nonsuicidal self-injury.

Julian Koenig, Lena Rinnewitz, Marco Warth, Thomas K Hillecke, Romuald Brunner, Franz Resch, Michael Kaess

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. [Efficacy evaluation of repeated transcranial magnetic stimulation combined with bipolar depression triple therapy in reducing female adolescents' non-suicidal self-injury].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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  18. [Advances in the electrophysiological research on neurocognitive function in adolescents with non-suicidal self-injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Julian KoenigFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Lena RinnewitzFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Marco WarthFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Thomas K HilleckeFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Romuald BrunnerFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Franz ReschFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
Michael KaessFrom the Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Koenig, Rinnewitz, Kaess); the Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Rinnewitz, Brunner, Resch, Kaess); and the School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany (Warth, Hillecke).
SRH Hochschule Heidelberg · DEAmerican Academy of Child and Adolescent Psychiatry · USHeidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonsuicidal self-injury (NSSI) is associated with reduced pain sensitivity and alterations in top-down processing of nociceptive information. The experience of acute pain is characterized by reactivity of the autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis, which to our knowledge has not been systematically investigated in the context of NSSI.

methodsAdolescents fulfilling DSM-5 diagnostic criteria for NSSI and matched healthy controls received cold pain stimulation. We obtained self-reports on psychological distress and measured blood pressure, heart rate variability (HRV) and saliva cortisol. Regression analyses were used to investigate group differences on observed difference scores, adjusting for confounding variables.

resultsWe included 30 adolescents engaging in NSSI and 30 controls in our study. Adolescents in the NSSI group showed a greater pain threshold. Groups significantly differed in their psychological response to pain. In patients with NSSI, mood and body awareness increased after painful stimulation; in controls it decreased. Tension increased in controls only. The HPA axis response to painful stimulation was increased in the NSSI compared with the control group. Analysis of ultra-short-term recordings of HRV revealed significant group differences during the anticipation of pain and recovery. LIMITATIONS: Future studies should incorporate multiple measures of saliva cortisol and replicate the present findings in a naturalistic setting.

conclusionCompared with controls, individuals engaging in NSSI show psychological benefits in response to pain. Biological findings highlight decreased physiologic arousal before and prolonged arousal (ANS and HPA axis response) after painful stimulation in adolescents engaging in NSSI. Greater pain-inflicted autonomic arousal and cortisol secretion may counteract dissociative states, reduce negative affect and increase body awareness in adolescents engaging in NSSI, lending support for a neurobiological pathomechanism underlying the intraindividual and antisuicide functions of NSSI.

Indexed as

AdolescentAffectAnticipation, PsychologicalAwarenessBlood PressureCase-Control StudiesChildFemaleHeart RateHumansHydrocortisoneInterview, PsychologicalPainPain ThresholdRegression AnalysisSalivaHydrocortisone

Identifiers

PMID28234208
PMCPMC5403664
OpenAlexW2593648039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.