Evidence map›Paper›PMID 28234206›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Bipolar disorder risk gene

Joseph J Shenker, Sarojini M Sengupta, Ridha Joober, Ashok Malla, M Mallar Chakravarty, Martin Lepage

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph J ShenkerFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
Sarojini M SenguptaFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
Ridha JooberFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
Ashok MallaFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
M Mallar ChakravartyFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
Martin LepageFrom the Douglas Mental Health University Institute, Montreal, Que., Canada (Shenker, Sengupta, Joober, Malla, Chakravarty, Lepage); the Integrated Program in Neuroscience, McGill University, Montreal, Que., Canada (Shenker, Lepage); the Department of Psychiatry, McGill University, Montreal, Que., Canada (Sengupta, Joober, Malla, Chakravarty, Lepage); and the Department of Biomedical Engineering, McGill University, Montreal, Que., Canada (Chakravarty).
Douglas Mental Health University Institute · CAMcGill University · CA

Funding

CIHR 68961
6 · The paper itself

Abstract

backgroundDespite being diagnostically associated uniquely with schizophrenia, negative symptoms are also observed in bipolar disorder (BD). Genome-wide association studies (GWAS) have uncovered a number of shared risk genes between schizophrenia and BD. The objectives of this study were to examine whether previously identified risk genes for BD are associated with negative symptom severity within a first-episode schizophrenia (FES) cohort and to examine whether such genes influence brain morphology.

methodsPatients experiencing FES were genotyped for 21 previously identified BD risk genes; a series of univariate analyses of covariance examined the association between negative symptom severity, as measured using the Scale for the Assessment of Negative Symptoms (SANS), and genotype. A subset of participants underwent a structural 1.5 T MRI

resultsWe included 133 patients with FES in our analysis; 61 of them underwent structural MRI. We observed a significant association between negative symptom severity and the BD risk gene LIMITATIONS: Limitations of this study include its modest sample size and lack of a control sample.

conclusionLacking the

Indexed as

Bipolar DisorderBrainFemaleForkhead Transcription FactorsGenetic Predisposition to DiseaseGenotyping TechniquesHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMultivariate AnalysisNeuropsychological TestsOrgan SizePolymorphism, Single NucleotidePsychiatric Status Rating ScalesSchizophreniaForkhead Transcription FactorsFOXO6 protein, human

Identifiers

PMID28234206
PMCPMC5403662
OpenAlexW2608083504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.