ArticleEpigenomics2017
Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period.
Article in Epigenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 3 of them syntheses that pooled it.
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Who cites it
80 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis.Epigenetics · 2023Pooled it
- Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization.Biology of sex differences · 2020Pooled it
- Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.Mutation research. Reviews in mutation researchPooled it
- Prenatal cell-free DNA methylome detects association with autism and maternal obesity.Communications biology · 2026Article
- Neonatal inflammation predicts adolescent brain volume and neurologic outcomes in children born extremely prematurely.Scientific reports · 2026Article
- Epigenetic mechanisms linking the perinatal environment, the placenta, and maternal and child health outcomes: evidence for sexual dimorphism.Environmental epigenetics · 2026Article
- Association of in utero exposure to phthalate and DINCH metabolites with placental DNA methylation.Environment international · 2025Article
- The placenta as a window into neonatal brain injury.Seminars in perinatology · 2025Review
- Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy.Clinical epigenetics · 2025Article
- Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.Pediatric research · 2025Article
- Placental DNA methylation key topics: sex- and cell-type specificity, mediation, multi-omics, and biomarker discovery.Epigenomics · 2025Review
- From Womb to Mind: Prenatal Epigenetic Influences on Mental Health Disorders.International journal of molecular sciences · 2025Review
- Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts.Journal of developmental origins of health and disease · 2025Article
- Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases.Nature communications · 2025Article
- Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2.Nutrients · 2025Review
- Article
- Placental DNA methylation in caesarean sections - a pilot study.Archives of medical science : AMS · 2025Article
- The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk.American journal of human genetics · 2024Article
- Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.Pediatric research · 2024Article
- Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids.Pediatric research · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimSex-based differences in response to adverse prenatal environments and infant outcomes have been observed, yet the underlying mechanisms for this are unclear. The placental epigenome may be a driver of these differences.
methodsPlacental DNA methylation was assessed at more than 480,000 CpG sites from male and female infants enrolled in the extremely low gestational age newborns cohort (ELGAN) and validated in a separate US-based cohort. The impact of gestational age on placental DNA methylation was further examined using the New Hampshire Birth Cohort Study for a total of n = 467 placentas.
resultsA total of n = 2745 CpG sites, representing n = 587 genes, were identified as differentially methylated (p < 1 × 10
conclusionThese data highlight sex-dependent epigenetic patterning in the placenta and provide insight into differences in infant outcomes and responses to the perinatal environment.
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