ArticleScientific reports2017
Inhibition of Cronobacter sakazakii Virulence Factors by Citral.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- Chemotypic Diversity, Antioxidant, Antimicrobial, and Antibiofilm Activities of Essential Oils from Arid-GrownMolecules (Basel, Switzerland) · 2026Article
- Leveraging the antibacterial and antibiofilm activities of Cymbopogon flexuosus essential oil against multidrug-resistant bacteria recovered from avian colibacillosis and bovine mastitis: in vitro and molecular docking insights.Veterinary research communications · 2026Article
- Lipidome Disturbances ofMicroorganisms · 2026Article
- Antimicrobial and anti-inflammatory properties ofMicrobiology (Reading, England) · 2026Article
- Investigating the Effect of Melittin Peptide in Preventing Biofilm Formation, Adhesion and Expression of Virulence Genes in Listeria monocytogenes.Probiotics and antimicrobial proteins · 2025Article
- Mechanisms and Applications of Citral's Antimicrobial Properties in Food Preservation and Pharmaceuticals Formulations.Antibiotics (Basel, Switzerland) · 2023Review
- The Genotyping Diversity and Hemolytic Activity ofFoods (Basel, Switzerland) · 2023Article
- Antibacterial Activity of Juglone Revealed in a Wound Model ofInternational journal of molecular sciences · 2023Article
- Inhibitory effects of hexanal on acylated homoserine lactones (AHLs) production to disrupt biofilm formation and enzymes activity inJournal of food science and technology · 2023Article
- The Antimicrobial and Antibiofilm Activity of Oregano Essential Oil againstFoods (Basel, Switzerland) · 2022Article
- Antibacterial Effect of Oregano Essential Oil againstFoods (Basel, Switzerland) · 2022Article
- Antimicrobial Activity and Action Mechanism of Thymoquinone againstFoods (Basel, Switzerland) · 2021Article
- Control of FoodborneFoods (Basel, Switzerland) · 2021Article
- Eugenol, citral, and hexanal, alone or in combination with heat, affect viability, biofilm formation, and swarming on Shiga-toxin-producingFood science and biotechnology · 2021Article
- Approaches to prevent and control Campylobacter spp. colonization in broiler chickens: a review.Environmental science and pollution research international · 2021Review
- Negative Impact of Citral on Susceptibility ofFrontiers in microbiology · 2021Article
- Current and Future Perspectives on the Role of Probiotics, Prebiotics, and Synbiotics in Controlling PathogenicFrontiers in microbiology · 2021Review
- Article
- Anti-quorum sensing and biofilm inhibitory activity ofJournal of food science and technology · 2020Article
- Lemon Grass Essential Oil Does not Modulate Cancer Cells Multidrug Resistance by Citral-Its Dominant and Strongly Antimicrobial Compound.Foods (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cronobacter sakazakii is a foodborne pathogen associated with fatal forms of necrotizing enterocolitis, meningitis and sepsis in neonates and infants. The aim of this study was to determine whether citral, a major component of lemongrass oil, could suppress putative virulence factors of C. sakazakii that contribute to infection. Sub-inhibitory concentrations of citral significantly decreased motility, quorum sensing, biofilm formation and endotoxin production. Citral substantially reduced the adhesion and invasion of C. sakazakii to Caco-2 cells and decreased bacterial survival and replication within the RAW 264.7 macrophage cells. Citral also repressed the expression of eighteen genes involved in the virulence. These findings suggest that citral has potential to be developed as an alternative or supplemental agent to mitigate the infections caused by C. sakazakii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.