ArticleScientific reports2017
Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of Red Blood Cell Biomechanics in the Setting of Cancer-Associated Anemia and Chemotherapy.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Red Blood Cell Deformability in Microfluidic Constrictions Under Flow and Wall Contact.Micromachines · 2026Article
- Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus.Journal of advanced research · 2025Review
- Fatigue of red blood cells under periodic squeezes in ECMO.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Axial and Nonaxial Migration of Red Blood Cells in a Microtube.Micromachines · 2021Article
- Fabrication of Microparticles with Front-Back Asymmetric Shapes Using Anisotropic Gelation.Micromachines · 2021Article
- Rotational manipulation of a microscopic object inside a microfluidic channel.Biomicrofluidics · 2020Article
- Deformation of a Red Blood Cell in a Narrow Rectangular Microchannel.Micromachines · 2019Article
- On-Chip Cell Incubator for Simultaneous Observation of Culture with and without Periodic Hydrostatic Pressure.Micromachines · 2019Article
- Microfluidic preparation of anchored cell membrane sheets for in vitro analyses and manipulation of the cytoplasmic face.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large deformability of erythrocytes in microvasculature is a prerequisite to realize smooth circulation. We develop a novel tool for the three-step "Catch-Load-Launch" manipulation of a human erythrocyte based on an ultra-high speed position control by a microfluidic "robotic pump". Quantification of the erythrocyte shape recovery as a function of loading time uncovered the critical time window for the transition between fast and slow recoveries. The comparison with erythrocytes under depletion of adenosine triphosphate revealed that the cytoskeletal remodeling over a whole cell occurs in 3 orders of magnitude longer timescale than the local dissociation-reassociation of a single spectrin node. Finally, we modeled septic conditions by incubating erythrocytes with endotoxin, and found that the exposure to endotoxin results in a significant delay in the characteristic transition time for cytoskeletal remodeling. The high speed manipulation of erythrocytes with a robotic pump technique allows for high throughput mechanical diagnosis of blood-related diseases.
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