Evidence map›Paper›PMID 28233238›Full record

ReviewCurrent hypertension reports2017

Plasticity of Renin Cells in the Kidney Vasculature.

R Ariel Gomez, Maria Luisa S Sequeira Lopez

Abstract readReview
In one paragraph

Review in Current hypertension reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Renin Cells, the Kidney, and Hypertension.Circulation research · 2021
    Review
  7. Article
  8. Article
  9. Development of the renal vasculature.Seminars in cell & developmental biology · 2019
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R Ariel GomezUniversity of Virginia School of Medicine, Child Health Research Center, 409 Lane Road, MR4 Building Room 2001, Charlottesville, VA, 22908, USA. rg@virginia.edu.
Maria Luisa S Sequeira LopezUniversity of Virginia School of Medicine, Child Health Research Center, 409 Lane Road, MR4 Building Room 2001, Charlottesville, VA, 22908, USA.

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 2012 to 2026
$13.8M
Renin Cell Fate in the Kidney VasculatureR37HL066242 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2007 to 2016
$4.0M
Development of the Renal ArteriolesR01DK091330 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2011 to 2015
$1.7M
NHLBI NIH HHS R37 HL066242NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK091330
6 · The paper itself

Abstract

During development, renin cells are precursors for arteriolar smooth muscle, mesangial cells, and interstitial pericytes. Those seemingly differentiated descendants retain the memory to re-express renin when there is a threat to homeostasis. Understanding how such molecular memory is constructed and regulated would be crucial to comprehend cell identity which is, in turn, intimately linked to homeostasis.

Indexed as

Cell PlasticityAnimalsHomeostasisHumansJuxtaglomerular ApparatusKidneyReninReninCell fateCell identityCell memoryCell numberRecruitment

Identifiers

PMID28233238
PMCPMC5734911

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.