SynthesisEuropean child & adolescent psychiatry2017
Gray matter abnormalities in pediatric autism spectrum disorder: a meta-analysis with signed differential mapping.
Synthesis in European child & adolescent psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04119492 (Integrating Brain Imaging and Rehabilitation to Improve Outcomes for Children With Co-occurring DCD & ASD), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrating Brain Imaging and Rehabilitation to Improve Outcomes for Children With Co-occurring DCD & ASD
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.Human brain mapping · 2019Pooled it
- Gaze-Speech Coordination During Narration in Autism Spectrum Disorder and First-Degree Relatives.Brain sciences · 2026Article
- The Genetic Landscape of Autism in Iran: A Systematic Review.Iranian journal of psychiatry · 2026Review
- Associations between vitamin D and brain volume in children with autism spectrum disorder.Pediatric research · 2025Article
- GM-VGG-Net: A Gray Matter-Based Deep Learning Network for Autism Classification.Diagnostics (Basel, Switzerland) · 2025Article
- Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits.European child & adolescent psychiatry · 2025Article
- Leveraging TabTransformer Deep Learning on Conventional MRI Radiomics for Accessible and Interpretable Diagnosis of Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2025Article
- Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings.Developmental neuroscience · 2025Article
- Altered prefrontal and cerebellar parvalbumin neuron counts are associated with cognitive changes in male rats.Experimental brain research · 2024Article
- Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults.Molecular autism · 2024Article
- Differences in regional brain structure in toddlers with autism are related to future language outcomes.Nature communications · 2024Article
- Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.European child & adolescent psychiatry · 2024Article
- Cortical grey matter volume differences in children with developmental coordination disorder compared to typically developing children.Frontiers in human neuroscience · 2024Article
- Brain structure variation and individual differences in theory of mind among older adults.Aging brain · 2024Article
- The Cerebellum-Ventral Tegmental Area Microcircuit and Its Implications for Autism Spectrum Disorder: A Narrative Review.Neuropsychiatric disease and treatment · 2024Review
- Study of Pragmatic Skills of Persian-speaking Adults with Autism Spectrum Disorder Based on the Persian Version of Montreal Protocol for the Evaluation of Communication (P.M.E.C.).Medical journal of the Islamic Republic of Iran · 2024Article
- Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing.Translational psychiatry · 2023Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gray matter abnormalities revealed by magnetic resonance imaging are inconsistent, especially in pediatric individuals with autism spectrum disorder (ASD) (age < 18 years old), a phenomenon possibly related to the core pathophysiology of ASD. The purpose of our meta-analysis was to identify and map the specific gray matter abnormalities in pediatric ASD individuals thereby exploring the potential effects of clinical and demographic characteristics of these gray matter changes. A systematic search was conducted to identify voxel-based morphometry studies in pediatric individuals with ASD. The effect-size signed differential mapping method was used to quantitatively estimate the regional gray matter abnormalities in pediatric ASD individuals. Meta-regression was used to examine the associations among age, gender, intelligence quotient, symptom severity and gray matter changes. Fifteen studies including 364 pediatric individuals with ASD (male = 282, age = 10.3 ± 4.4 years) and 377 healthy controls (male = 289, age = 10.5 ± 4.2 years) were included. Pediatric ASD individuals showed significant gray matter increases in the right angular gyrus, left superior and middle frontal gyrus, left precuneus, left inferior occipital gyrus and right inferior temporal gyrus, most of which involving the default mode network, and decreases in the left cerebellum and left postcentral gyrus. The meta-regression analysis showed that the repetitive behavior scores of the Autism Diagnostic Interview-Revised were positively associated with increased gray matter volumes in the right angular gyrus. Increased rather than decreased gray matter volume, especially involving the angular gyrus and prefrontal cortex may be the core pathophysiology in the early course of ASD.
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Registered trials
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