ArticleHernia : the journal of hernias and abdominal wall surgery2017
Hernia repair with polypropylene mesh is not associated with an increased risk of autoimmune disease in adult men.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06363903 (Autoimmume/Inflammatory Syndrome Induced by Adjuvants), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autoimmume/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) Caused by Polypropylene Mesh Implantation - a Pilot Study for Diagnostics and Treatment
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Autoimmunity and hernia mesh: fact or fiction?Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Are polypropylene mesh implants associated with systemic autoimmune inflammatory syndromes? A systematic review.Hernia : the journal of hernias and abdominal wall surgery · 2022Pooled it
- Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence.Nature reviews. Urology · 2026Article
- Reply to 'Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence'.Nature reviews. Urology · 2026Article
- Incidence of autoimmune disease after hernia surgery with a mesh implant: national retrospective cohort study.The British journal of surgery · 2026Article
- Effects of degradation-associated polypropylene particles in the surrounding tissue after surgical mesh implantation.Nature reviews. Urology · 2025Article
- Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation - Protocol of a Pilot Study for Diagnostics and Treatment.Journal of abdominal wall surgery : JAWS · 2025Article
- Pain following hernia repair: awareness is crucial.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Impact of a mid-urethral synthetic mesh sling on long-term risk of systemic conditions in women with stress urinary incontinence: a national cohort study.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Phenol-Soluble Modulins FromFrontiers in cellular and infection microbiology · 2022Article
- Polypropylene mesh and systemic side effects in inguinal hernia repair: current evidence.Irish journal of medical science · 2019Review
- Bacterial Amyloids: The Link between Bacterial Infections and Autoimmunity.Trends in microbiology · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSynthetic mesh for herniorrhaphy has been placed under critical observation regarding the potential association of mesh placement and the subsequent development of autoimmune diseases. We sought to evaluate whether there is a link between synthetic polypropylene mesh repairs and the subsequent development of systemic/autoimmune disorders (SAID). STUDY
designAdult men undergoing hernia repair with mesh between January 2008 and December 2009 in New York State were identified using International Classification of Diseases, Ninth Revision, Modification procedure codes and Current Procedural Terminology Coding System, Fourth Edition codes. A control cohort of men undergoing colonoscopy was created with whom to compare outcomes.
resultsA total of 29,712 patients underwent hernia repair between January 2008 and December 2009. In the control cohort, 79,265 patients underwent colonoscopy. During the entire follow-up, 475 patients undergoing hernia repair and 1305 patients in the control cohort were diagnosed with autoimmune disease. When patients were matched based on demographics, comorbidities and procedure date, hernia repair was not associated with an increased risk of developing autoimmune disease over the entire follow-up time period. 1.6% of those in the hernia group vs. 1.7% of those in the colonoscopy group developed SAID [risk ratio (95% CI): hernia vs. colonoscopy 0.93(0.79-1.09)]. No association between mesh surgery and increased risks of SAID was found at any of the specified time points (6 months, 1 year, and 2-year follow-up).
conclusionsMesh-based hernia repair was not associated with the development of autoimmune diseases compared to those undergoing routine screening colonoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.