Evidence map›Paper›PMID 28233049›Full record

ArticleImmunogenetics2017

A haplotype spanning P2X7R, P2X4R and CAMKK2 may mark susceptibility to pulmonary non-tuberculous mycobacterial disease.

Samuel Halstrom, Catherine L Cherry, Michael Black, Rachel Thomson, Hayley Goullee, Svetlana Baltic, Richard Allcock, Suzanna E L Temple, Patricia Price

Abstract read
PubMed Publisher
In one paragraph

Article in Immunogenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Pulmonary non-tuberculous mycobacterial infections: current state and future management.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Samuel HalstromSchool of Medicine and Biomedical Science, University of Queensland, QLD, Brisbane, Australia.
Catherine L CherryCentre for Biomedical Research, Burnet Institute, and Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, VIC, Australia.
Michael BlackCentre for Comparative Genomics, Murdoch University, Perth, WA, Australia.
Rachel ThomsonSchool of Medicine and Biomedical Science, University of Queensland, QLD, Brisbane, Australia.
Hayley GoulleeHarry Perkins Institute of Medical Research, Perth, WA, Australia.
Svetlana BalticInstitute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.
Richard AllcockTranslational Cancer Pathology Laboratory, PathWest Laboratory Medicine W.A, Nedlands, WA, Australia.
Suzanna E L TempleInstitute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.
Patricia PriceSchool of Biomedical Science, Curtin University, Perth, WA, Australia. patricia.price@curtin.edu.au.
University of Western Australia · AUBurnet Institute · AUGreenslopes Private Hospital · AUHarry Perkins Institute of Medical Research · AUMurdoch University · AUPathwest Laboratory Medicine · AUUniversity of Queensland · AUUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite widespread exposure to potentially pathogenic mycobacteria present in the soil and in domestic water supplies, it is not clear why only a small proportion of individuals contract pulmonary nontuberculous mycobacterial (NTM) infections. Here, we explore the impact of polymorphisms within three genes: P2X ligand gated ion channel 7 (P2X7R), P2X ligand gated ion channel 4 (P2X4R) and calcium/calmodulin-dependent protein kinase kinase 2 beta (CAMKK2) on susceptibility. Thirty single nucleotide polymorphisms (SNPs) were genotyped in NTM patients (n = 124) and healthy controls (n = 229). Weak associations were found between individual alleles in P2X7R and disease but were not significant in multivariate analyses adjusted to account for gender. Haplotypes spanning the three genes were derived using the fastPHASE algorithm. This yielded 27 haplotypes with frequencies >1% and accounting for 63.3% of the combined cohort. In univariate analyses, seven of these haplotypes displayed associations with NTM disease above our preliminary cut-off (p ≤ 0.20). When these were carried forward in a logistic regression model, gender and one haplotype (SH95) were independently associated with the disease (model p < 0.0001; R

Indexed as

MycobacteriumPolymorphism, Single NucleotideAdultAgedAged, 80 and overCalcium-Calmodulin-Dependent Protein Kinase KinaseCase-Control StudiesFemaleGenetic Predisposition to DiseaseHaplotypesHumansLung DiseasesMaleMiddle AgedMycobacterium Infections, NontuberculousReceptors, Purinergic P2X4Calcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanP2RX7 protein, humanReceptors, Purinergic P2X4Receptors, Purinergic P2X7Genetic polymorphismImmunogeneticsNon-tuberculous mycobacteriaPulmonary disease

Identifiers

PMID28233049
OpenAlexW2591209314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.