ArticleAnalytical and bioanalytical chemistry2017
Leaner and greener analysis of cannabinoids.
Article in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 70 citations in OpenAlex.
- Recent HPLC-UV Approaches for Cannabinoid Analysis: From Extraction to Method Validation and Quantification Compliance.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Chemical Profiling of Polyphenolic Fraction ofPlants (Basel, Switzerland) · 2025Article
- Challenges of Extracting and Determining Cannabinoids in Different Matrices.Cannabis and cannabinoid research · 2024Review
- The Development, Validation, and Application of a UHPLC-HESI-MS Method for the Determination of 17 Cannabinoids inMolecules (Basel, Switzerland) · 2023Article
- Study of Cannabis Oils Obtained from Three Varieties ofPlants (Basel, Switzerland) · 2023Article
- Modeling a pesticide remediation strategy for preparative liquid chromatography using high-performance liquid chromatography.Journal of cannabis research · 2023Article
- Semi-quantitative analysis of cannabinoids in hemp (Cannabis sativa L.) using gas chromatography coupled to mass spectrometry.Journal of cannabis research · 2022Article
- Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC.Scientific reports · 2022Article
- Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography.Analytical and bioanalytical chemistry · 2022Article
- Fast and reliable profiling of cannabinoids in seized samples using the method of HPLC-DAD followed by chemometrics.Forensic toxicology · 2022Article
- Cannabinoids-Characteristics and Potential for Use in Food Production.Molecules (Basel, Switzerland) · 2021Review
- Metabolomic Analysis of Cannabinoid and Essential Oil Profiles in Different Hemp (Plants (Basel, Switzerland) · 2021Article
- Development of Gas-Chromatographic Method for Simultaneous Determination of Cannabinoids and Terpenes in Hemp.Molecules (Basel, Switzerland) · 2020Article
- Quantitative determination and validation of 17 cannabinoids in cannabis and hemp using liquid chromatography-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2020Article
- (‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research.Molecules (Basel, Switzerland) · 2020Review
- A pharmacological characterization of Cannabis sativa chemovar extracts.Journal of cannabis research · 2020Article
- Interpol review of controlled substances 2016-2019.Forensic science international. Synergy · 2020Review
- Identification ofMolecules (Basel, Switzerland) · 2019Article
- Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method inMolecules (Basel, Switzerland) · 2019Article
- Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses.Cannabis and cannabinoid research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an explosion in the number of labs analyzing cannabinoids in marijuana (Cannabis sativa L., Cannabaceae) but existing methods are inefficient, require expert analysts, and use large volumes of potentially environmentally damaging solvents. The objective of this work was to develop and validate an accurate method for analyzing cannabinoids in cannabis raw materials and finished products that is more efficient and uses fewer toxic solvents. An HPLC-DAD method was developed for eight cannabinoids in cannabis flowers and oils using a statistically guided optimization plan based on the principles of green chemistry. A single-laboratory validation determined the linearity, selectivity, accuracy, repeatability, intermediate precision, limit of detection, and limit of quantitation of the method. Amounts of individual cannabinoids above the limit of quantitation in the flowers ranged from 0.02 to 14.9% w/w, with repeatability ranging from 0.78 to 10.08% relative standard deviation. The intermediate precision determined using HorRat ratios ranged from 0.3 to 2.0. The LOQs for individual cannabinoids in flowers ranged from 0.02 to 0.17% w/w. This is a significant improvement over previous methods and is suitable for a wide range of applications including regulatory compliance, clinical studies, direct patient medical services, and commercial suppliers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.