Trial reportBioMed research international2017
Evaluation of Laser Speckle Contrast Imaging for the Assessment of Oral Mucosal Blood Flow following Periodontal Plastic Surgery: An Exploratory Study.
Trial report in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06261268 (Strip Graft With Xenogeneic Matrix Versus Free Gingival Graft for the Augmentation of Peri-implant Keratinized Mucosa), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strip Graft With Xenogeneic Matrix Versus Free Gingival Graft for the Augmentation of Peri-implant Keratinized Mucosa: A Randomized Clinical Trial With Vascular Analysis
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Characterization of oral biomarkers during early healing at augmented dental implant sites.Journal of periodontal research · 2025Trial
- Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites.Journal of clinical periodontology · 2025Trial
- Flap perfusion of superficial split flap design for guided bone regeneration: A case report with ultrasonography.Clinical advances in periodontics · 2026Article
- Innovations in microsurgery: The role of non-invasive blood perfusion imaging-A review and framework.Clinical advances in periodontics · 2026Review
- Non-invasive and quantitative methods for assessment of blood flow in periodontal and oral soft tissues: a systematic review.Frontiers in dental medicine · 2025Review
- Biofabrication Strategies for Oral Soft Tissue Regeneration.Advanced healthcare materials · 2024Review
- Projection mapping system for laser speckle contrast image: feasibility study for clinical application.Journal of biomedical optics · 2023Article
- Optical spectral diagnostics of the oxygenation level in periodontal tissues and photodynamic therapy using methylene blue in children with cerebral palsy.Frontiers in public health · 2023Article
- Sex-related differences in endothelium-dependent vasodilation of human gingiva.BMC oral health · 2022Article
- The Structure and Function of Next-Generation Gingival Graft Substitutes-A Perspective on Multilayer Electrospun Constructs with Consideration of Vascularization.International journal of molecular sciences · 2022Review
- Identification of venular capillary remodelling: a possible link to the development of periodontitis?Journal of periodontal & implant science · 2022Article
- Revisiting the vascularity of the keratinized gingiva in the maxillary esthetic zone.BMC oral health · 2021Article
- Comprehensive review of surgical microscopes: technology development and medical applications.Journal of biomedical optics · 2021Review
- Epinephrine penetrates through gingival sulcus unlike keratinized gingiva and evokes remote vasoconstriction in human.BMC oral health · 2020Article
- Clinical applications of laser speckle contrast imaging: a review.Journal of biomedical optics · 2019Review
- Analysis of blood supply in the hard palate and maxillary tuberosity-clinical implications for flap design and soft tissue graft harvesting (a human cadaver study).Clinical oral investigations · 2019Article
- Blood perfusion in Hewes tarsoconjunctival flaps in pigs measured by laser speckle contrast imaging.JPRAS open · 2018Article
- Blood flow changes using a 3D xenogeneic collagen matrix or a subepithelial connective tissue graft for root coverage procedures: a pilot study.Clinical oral investigations · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcirculation of the modified coronally advanced tunnel technique (MCAT) for gingival recession coverage. Gingival microcirculation and wound fluid were measured before and after surgery for six months at twenty-seven treated teeth. In males, the flap microcirculation was restored within 3 days for both grafts followed by a hyperemic response. During the first 8 days the blood flow was higher at xenogeneic graft comparing to the CTG. In females, the ischemic period lasted for 7-12 days depending on the graft and no hyperemic response was observed. Females had more intense and prolonged wound fluid production. The LSCI method is suitable to capture the microcirculatory effect of the surgical intervention in human oral mucosa. The application of xenogeneic collagen matrices as a CTG substitute does not seem to restrain the recovery of graft bed circulation. Gender may have an effect on postoperative circulation and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.