ArticleIntrinsically disordered proteins2015
Missing strings of residues in protein crystal structures.
Article in Intrinsically disordered proteins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- MultilevelCurrent research in structural biology · 2026Article
- Novel pyridine-heterocycle hybrids: synthesisRSC advances · 2026Article
- Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae.Acta crystallographica. Section F, Structural biology communications · 2025Article
- AFFIPred: AlphaFold2 structure-based Functional Impact Prediction of missense variations.Protein science : a publication of the Protein Society · 2025Article
- Inferring molecular inhibition potency with AlphaFold predicted structures.Scientific reports · 2024Article
- Anti-angiogenic Potential of Trans-chalcone in anCardiovascular & hematological agents in medicinal chemistry · 2024Article
- Local Disordered Region Sampling (LDRS) for ensemble modeling of proteins with experimentally undetermined or low confidence prediction segments.Bioinformatics (Oxford, England) · 2023Article
- Integration of pre-trained protein language models into geometric deep learning networks.Communications biology · 2023Article
- Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments.bioRxiv : the preprint server for biology · 2023Article
- Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon.Communications biology · 2023Article
- Comprehensive in silico analyses of flavonoids elucidating the drug properties against kidney disease by targeting AIM2.PloS one · 2023Article
- Geometry-Based versus Small-Molecule Tracking Method for Tunnel Identification: Benefits and Pitfalls.Journal of chemical information and modeling · 2022Article
- Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation.The Biochemical journal · 2021Article
- Current approaches to flexible loop modeling.Current research in structural biology · 2021Review
- Simple Selection Procedure to Distinguish between Static and Flexible Loops.International journal of molecular sciences · 2020Article
- Role of Computational Methods in Going beyond X-ray Crystallography to Explore Protein Structure and Dynamics.International journal of molecular sciences · 2018Review
- Article
- How large B-factors can be in protein crystal structures.BMC bioinformatics · 2018Article
- Refining the macromolecular model - achieving the best agreement with the data from X-ray diffraction experiment.Crystallography reviews · 2018Article
- Packing topology in crystals of proteins and small molecules: a comparison.Scientific reports · 2017Article
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2 authors.
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Abstract
A large fraction of the protein crystal structures deposited in the Protein Data Bank are incomplete, since the position of one or more residues is not reported, despite these residues are part of the material that was analyzed. This may bias the use of the protein crystal structures by molecular biologists. Here we observe that in the large majority of the protein crystal structures strings of residues are missing. Polar residues incline to occur in missing strings together with glycine, while apolar and aromatic residues tend to avoid them. Particularly flexible residues, as shown by their extremely high B-factors, by their exposure to the solvent and by their secondary structures, flank the missing strings. These data should be a helpful guideline for crystallographers that encounter regions of flat and uninterpretable electron density as well as end-users of crystal structures.
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