ReviewFrontiers in physiology2017
Physiological Mechanisms of Eccentric Contraction and Its Applications: A Role for the Giant Titin Protein.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Mechanical, Material and Morphological Adaptations of Healthy Lower Limb Tendons to Mechanical Loading: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover Study.Nutrients · 2026Trial
- Starting length and temperature dependence of eccentric muscle force-velocity behaviour.The Journal of experimental biology · 2026Article
- How temperature tunes muscle mechanics during eccentric contractions.American journal of physiology. Cell physiology · 2026Article
- Cross-Education Effects After Submaximal and Supramaximal Accentuated Eccentric Loading on Lean Mass and Function in Women.Journal of functional morphology and kinesiology · 2026Article
- Acute Decrease in Glenohumeral Internal Rotation During Repetitive Baseball Pitching Is Associated with Transient Structural Changes in Medial Longitudinal Arch of Stride Leg: Pilot Study Using Mixed Model.Sports (Basel, Switzerland) · 2025Article
- Using Isometric Squat Strength to Predict Concentric and Eccentric Squat Strength in Young and Older Adults.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025Article
- Effect of Eccentric Training with Different Durations, Intensities, and Contraction Velocities on Upper Limb Muscle Strength: A Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Using 30-s Prone Back Extension Repetition Maximum Test to Predict Concentric and Eccentric 1 Repetition Maximum Squat Strength in Young and Older Adults.Journal of aging research · 2025Article
- Article
- Neurophysiology of ACL Injury.Orthopedic reviews · 2025Article
- Acute effects of supramaximal loaded back squat activation on countermovement jump performance, muscle mechanical properties, and skin surface temperature in powerlifters.European journal of sport science · 2025Article
- Peak Oxygen Uptake is Slope Dependent: Insights from Ground Reaction Forces and Muscle Oxygenation in Trained Male Runners.Sports medicine - open · 2024Article
- Effect of high-fat diet on isometric, concentric and eccentric contractile performance of skeletal muscle isolated from female CD-1 mice.Experimental physiology · 2024Article
- Physical Activity Fragmentation and Falls in Older Adults: Findings From the National Health and Aging Trends Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Repeated Bout Effect of Downhill Running on Physiological Markers of Effort and Post Exercise Perception of Soreness in Trained Female Distance Runners.Sports (Basel, Switzerland) · 2024Article
- The role of torso stiffness and prediction in the biomechanics of anxiety: a narrative review.Frontiers in sports and active living · 2024Review
- Evidence for multi-scale power amplification in skeletal muscle.The Journal of experimental biology · 2023Article
- Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity.Sports medicine - open · 2023Review
- What good is a measure of muscle length? The how and why of direct measurements of skeletal muscle motion.Journal of biomechanics · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When active muscles are stretched, our understanding of muscle function is stretched as well. Our understanding of the molecular mechanisms of concentric contraction has advanced considerably since the advent of the sliding filament theory, whereas mechanisms for increased force production during eccentric contraction are only now becoming clearer. Eccentric contractions play an important role in everyday human movements, including mobility, stability, and muscle strength. Shortly after the sliding filament theory of muscle contraction was introduced, there was a reluctant recognition that muscle behaved as if it contained an "elastic" filament. Jean Hanson and Hugh Huxley referred to this structure as the "S-filament," though their concept gained little traction. This additional filament, the giant titin protein, was identified several decades later, and its roles in muscle contraction are still being discovered. Recent research has demonstrated that, like activation of thin filaments by calcium, titin is also activated in muscle sarcomeres by mechanisms only now being elucidated. The
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.