ArticleNature communications2017
GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 152 citations in OpenAlex.
- Circadian Oscillations in Branchlet Angle and Irradiance-Dependent Acclimation inPlant direct · 2026Article
- FBXL21 regulates diurnal proteostasis in skeletal muscle by targeting DNAJB6 and client proteins.EMBO reports · 2026Article
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Early birds and night owls: natural variation of circadian traits in plants.Journal of experimental botany · 2026Review
- Dissecting usuranme biquitin-mediated circadian clock regulation in Arabidopsis via high-throughput yeast screens.Journal of experimental botany · 2025Article
- De novo transcriptome assembly and gene expression analysis of Cnidium officinale under high-temperature conditions.BMC genomics · 2025Article
- Abscisic acid and GIGANTEA signalling converge to regulate the recruitment of CONSTANS to the FT promoter and activate floral transition.Journal of experimental botany · 2025Article
- GIGANTEA Is Required for Robust Circadian Rhythms in Wheat.Plant, cell & environment · 2025Article
- USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization.Science advances · 2025Article
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Revisiting the role of light signaling in plant responses to salt stress.Horticulture research · 2025Article
- Forward genetic approach identifies a phylogenetically conserved serine residue critical for the catalytic activity of UBIQUITIN-SPECIFIC PROTEASE 12 in Arabidopsis.Scientific reports · 2024Article
- LIP1 Regulates the Plant Circadian Oscillator by Modulating the Function of the Clock Component GIGANTEA.Cells · 2024Article
- Comparative proteomics in tall fescue to reveal underlying mechanisms for improving Photosystem II thermotolerance during heat stress memory.BMC genomics · 2024Article
- Unlocking Nature's Rhythms: Insights into Secondary Metabolite Modulation by the Circadian Clock.International journal of molecular sciences · 2024Review
- Timely symbiosis: circadian control of legume-rhizobia symbiosis.Biochemical Society transactions · 2024Review
- Review
- The Roles of Circadian Clock Genes in Plant Temperature Stress Responses.International journal of molecular sciences · 2024Review
- GIGANTEA-ENHANCED EM LEVEL complex initiates drought escape response via dual function of ABA synthesis and flowering promotion.Plant signaling & behavior · 2023Article
- Inhibition of RNA degradation integrates the metabolic signals induced by osmotic stress into the Arabidopsis circadian system.Journal of experimental botany · 2023Article
12 more citing papers are in PubMed but not listed here.
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8 authors at 5 institutions in 3 countries.
Funding
Abstract
Circadian clock systems help establish the correct daily phasing of the behavioral, developmental, and molecular events needed for the proper coordination of physiology and metabolism. The circadian oscillator comprises transcription-translation feedback loops but also requires post-translational processes that regulate clock protein homeostasis. GIGANTEA is a unique plant protein involved in the maintenance and control of numerous facets of plant physiology and development. Through an unknown mechanism GIGANTEA stabilizes the F-box protein ZEITLUPE, a key regulator of the circadian clock. Here, we show that GIGANTEA has general protein chaperone activity and can act to specifically facilitate ZEITLUPE maturation into an active form in vitro and in planta. GIGANTEA forms a ternary complex with HSP90 and ZEITLUPE and its co-chaperone action synergistically enhances HSP90/HSP70 maturation of ZEITLUPE in vitro. These results identify a molecular mechanism for GIGANTEA activity that can explain its wide-ranging role in plant biology.The plant-specific GIGANTEA protein regulates the circadian clock by stabilizing the F-box protein ZEITLUPE via an unknown mechanism. Here Cha et al. show that GIGANTEA has intrinsic chaperone activity and can facilitate ZEITLUPE maturation by acting synergistically with HSP90.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.