Evidence map›Paper›PMID 28232604›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

α- Versus β-Emitting Radionuclides for Pretargeted Radioimmunotherapy of Carcinoembryonic Antigen-Expressing Human Colon Cancer Xenografts.

Sandra Heskamp, Reinier Hernandez, Janneke D M Molkenboer-Kuenen, Markus Essler, Frank Bruchertseifer, Alfred Morgenstern, Erik J Steenbergen, Weibo Cai, Christof Seidl, William J McBride and 2 more

Abstract readComparative Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Enhanced Antitumor Efficacy ofInternational journal of radiation oncology, biology, physics · 2026
    Article
  2. PretargetedTheranostics · 2026
    Article
  3. A high-affinity CEA-targeted nanobody forJournal of nanobiotechnology · 2025
    Article
  4. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a BivalentJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Review
  11. Efficacy of HER2-Targeted IntraperitonealJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Article
  13. Pretargeting: A Path Forward for Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  14. Article
  15. Frontiers in oncology · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sandra HeskampDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands sandra.heskamp@radboudumc.nl.
Reinier HernandezMedical Physics Department, University of Wisconsin-Madison, Madison, Wisconsin.
Janneke D M Molkenboer-KuenenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Markus EsslerKlinik und Poliklinik fur Nuklearmedizin, University of Bonn, Bonn, Germany.
Frank BruchertseiferEuropean Commission, Joint Research Centre-Directorate for Nuclear Safety and Security, Karlsruhe, Germany.
Alfred MorgensternEuropean Commission, Joint Research Centre-Directorate for Nuclear Safety and Security, Karlsruhe, Germany.
Erik J SteenbergenDepartment of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Weibo CaiMedical Physics Department, University of Wisconsin-Madison, Madison, Wisconsin.
Christof SeidlDepartment of Nuclear Medicine, Technische Universität München, Munich, Germany.
William J McBrideImmunomedics, Inc., Morris Plains, New Jersey.
David M GoldenbergImmunomedics, Inc., Morris Plains, New Jersey.
Otto C BoermanDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS R01 CA169365NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Pretargeted radioimmunotherapy (PRIT) with the β-emitting radionuclide

Indexed as

Alpha ParticlesAnimalsBeta ParticlesCarcinoembryonic AntigenCell Line, TumorColonic NeoplasmsFemaleMiceMice, Inbred BALB CMice, NudeMolecular Targeted TherapyRadioimmunotherapyRadioisotopesTreatment OutcomeCarcinoembryonic AntigenRadioisotopesBi-213CEApretargetingradiochemistryradionuclide therapytargeted alpha therapy

Identifiers

PMID28232604
PMCPMC5450366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.